{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:14:29Z","timestamp":1790403269289,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":4509,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[1992,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cellular constituents of the placenta are important participants in the recruitment and trafficking of inflammatory cells within the placenta. In infectioninduced labor, gestational tissues synthesize and release a variety of inflammatory cytokines whose effects include increased prostaglandin biosynthesis and the initiation of uterine contractions. Interleukin\u20108 (IL\u20108), a potent neutrophil chemoattractant, has been recently described as being elevated in the amniotic fluid of mothers with chorioamnionitis. We investigated the biosynthesis of IL\u20108 by human amnion cells and its regulation by other inflammatory cytokines. Cultured amnion cells obtained from normal term placentae were found to produce IL\u20108 in response to pathophysiologic concentrations of interleukin 1\u03b2 (IL\u20101\u03b2) and tumor necrosis factor alpha (TNF\u2010\u03b1). Treatment of amnion cells stimulated by IL\u20101\u03b2 with cycloheximide resulted in increased IL\u20108 production, while incubation of IL\u20101\u03b2 treated amnion cells with actinomycin D resulted in a concentration\u2010dependent decrease in detectable amounts of IL\u20108. Northern blot analysis of cultured amnion cells stimulated with IL\u20101\u03b2 demonstrated a rapid increase in IL\u20108 mRNA which peaked at 2\u20134 hr. These in vitro result suggest inflammation of gestational tissues in vivo may result in locally produced IL\u20108 and, in association with other inflammatory mediators, may be important in the pathophysiology of infection\u2010induced labor. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.1041530107","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T07:01:26Z","timestamp":1109401286000},"page":"38-43","source":"Crossref","is-referenced-by-count":44,"title":["Amnion cell biosynthesis of interleukin\u20108: Regulation by inflammatory cytokines"],"prefix":"10.1002","volume":"153","author":[{"given":"Michael S.","family":"Trautman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"Dudley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel S.","family":"Edwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Collmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray D.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"335","volume-title":"Danforth's Obstetrics and Gynecology","author":"Anderson H. 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