{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:47:38Z","timestamp":1761058058261},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,4]],"date-time":"2004-10-04T00:00:00Z","timestamp":1096848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cellular proto\u2010oncogene <jats:italic>c\u2010myc<\/jats:italic> is an important transcription factor that plays a role in several cellular activities such as proliferation, differentiation, and apoptosis. It follows that regulation of <jats:italic>c\u2010myc<\/jats:italic> expression is crucial for maintaining cell integrity. Amplification or translocation can convert this proto\u2010oncogene into an activated oncogene, thereby deregulating <jats:italic>c\u2010myc<\/jats:italic> expression. Changes in the expression of <jats:italic>c\u2010myc<\/jats:italic> leading to malignant cell growth and tumor progression can also be triggered by extrinsic factors. It has been reported that iron can increase cell proliferation, mainly by stimulating DNA synthesis as well as by enhancing <jats:italic>c\u2010myc<\/jats:italic> expression. Here, we studied the effect of iron on cells in which <jats:italic>c\u2010myc<\/jats:italic> expression is deregulated by either chromosomal translocation or gene amplification. When added to Burkitt's lymphoma cell lines, iron markedly inhibits cell proliferation. This effect is mediated by a cell cycle arrest in G<jats:sub>2<\/jats:sub>\/M, followed by an important decrease in <jats:italic>c\u2010myc<\/jats:italic> expression, whereas no effect could be observed in a cell line harboring amplified <jats:italic>c\u2010myc<\/jats:italic>. Moreover, the down\u2010regulation of <jats:italic>c\u2010myc<\/jats:italic> expression, which is independent from cell cycle blockade, leads to cell death by apoptosis. Collectively, our results suggest the existence of a novel iron\u2010dependent cell cycle regulatory mechanism involving modulation of translocated <jats:italic>c\u2010myc<\/jats:italic> gene expression. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.20229","type":"journal-article","created":{"date-parts":[[2004,10,4]],"date-time":"2004-10-04T20:01:22Z","timestamp":1096920082000},"page":"277-285","source":"Crossref","is-referenced-by-count":9,"title":["Iron specific growth inhibition of Burkitt's lymphoma cells in vitro, associated with a decrease in translocated <i>c\u2010myc<\/i> expression"],"prefix":"10.1002","volume":"203","author":[{"given":"Marie\u2010Eve","family":"Habel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9al","family":"Lemieux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8478"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1983.tb01749.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.168.195"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.6.1.71"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204595"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2452485"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60200-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1684"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb04140.x"},{"issue":"12","key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1093\/jn\/128.12.2295","article-title":"Iron 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