{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:24:39Z","timestamp":1791296679201,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,1,12]],"date-time":"2005-01-12T00:00:00Z","timestamp":1105488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Micro RNAs (miRs) are small noncoding RNAs, functioning as antisense regulators of other RNAs. <jats:italic>miR\u201015a<\/jats:italic> and <jats:italic>miR\u201016\u20101<\/jats:italic> genes are located at chromosome 13q14, a region which is frequently deleted in pituitary tumors. An inverse correlation has been shown in B cell chronic lymphocytic leukemia (B\u2010CLL) between miR\u201015a and miR\u201016\u20101 expression and the expression levels of arginyl\u2010tRNA synthetase (RARS), an enzyme which associates with the cofactor p43 in the aminoacyl\u2010tRNA synthetase complex. When secreted, p43 regulates local inflammatory response and macrophage chemotaxis, and seems to have anti\u2010neoplastic properties in mice. We explored miR\u201015a and miR\u201016\u20101 expression in 10 GH\u2010secreting and in 10 PRL\u2010secreting pituitary macroadenomas by Northern blot, and investigated the possible correlation with in vivo and in vitro characteristics. We found that miR\u201015a and miR\u201016\u20101 are expressed at lower levels in pituitary adenomas as compared to normal pituitary tissue. Moreover, their expression inversely correlates with tumor diameter and with RARS expression (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), but directly correlates with p43 secretion (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.02). Therefore, <jats:italic>miR15<\/jats:italic> and <jats:italic>miR16<\/jats:italic> down\u2010regulation in pituitary adenomas correlates with a greater tumor diameter and a lower p43 secretion, suggesting that these genes may, at least in part, influence tumor growth. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.20282","type":"journal-article","created":{"date-parts":[[2005,1,12]],"date-time":"2005-01-12T17:16:23Z","timestamp":1105550183000},"page":"280-285","source":"Crossref","is-referenced-by-count":292,"title":["miR\u201015a and miR\u201016\u20101 down\u2010regulation in pituitary adenomas"],"prefix":"10.1002","volume":"204","author":[{"given":"Arianna","family":"Bottoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Piccin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Tagliati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Luchin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Zatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore C.","family":"Degli 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