{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:33:02Z","timestamp":1791232382284,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T00:00:00Z","timestamp":1166745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A family of co\u2010chaperone proteins that share the Bcl\u20102\u2010associated athanogene (BAG) domain are involved in a number of cellular processes, including proliferation and apoptosis. Among these proteins, BAG3 has received increased attention due to its high levels in several disease models and ability to associate with Hsp70 and a number of other molecular partners. BAG3 expression is stimulated during cell response to stressful conditions, such as exposure to high temperature, heavy metals, and certain drugs. Here, we demonstrate that BAG3 expression is elevated upon HIV\u20101 infection of human lymphocytes and fetal microglial cells. Furthermore, BAG3 protein was detectable in the cytoplasm of reactive astrocytes in HIV\u20101\u2010associated encephalopathy biopsies, suggesting that induction of BAG3 is part of the host cell response to viral infection. To assess the impact of BAG3 upregulation on HIV\u20101 gene expression, we performed transcription assays and demonstrated that BAG3 can suppress transcription of the HIV\u20101 long terminal repeat (LTR) in microglial cells. This activity was mapped to the \u03baB motif of the HIV\u20101 LTR. Results from in vitro and in vivo binding assays revealed that BAG3 suppresses interaction of the p65 subunit of NF\u2010\u03baB with the \u03baB DNA motif of the LTR. Results from binding and transcriptional assay identified the C\u2010terminus of BAG3 as a potential domain involved in the observed inhibitory effect of BAG3 on p65 activity. These observations reveal a previously unrecognized cell response, that is, an increase in BAG3, elicited by HIV\u20101 infection, and may provide a new avenue for the suppression of HIV\u20101 gene expression. J. Cell. Physiol. 210: 676\u2013683, 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.20865","type":"journal-article","created":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T14:52:05Z","timestamp":1166799125000},"page":"676-683","source":"Crossref","is-referenced-by-count":62,"title":["Evidence for BAG3 modulation of HIV\u20101 gene transcription"],"prefix":"10.1002","volume":"210","author":[{"given":"Alessandra","family":"Rosati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Leone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Del Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohreh","family":"Amini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel","family":"Khalili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Caterina","family":"Turco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280390194073"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205754"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5512"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26471"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403219"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.11.6858"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/86236"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202792200"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2004.05.002"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20612"},{"key":"e_1_2_5_12_1","first-page":"37","article-title":"Novel partner proteins of adenovirus penton","volume":"272","author":"Chroboczek J","year":"2003","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-2586-5_8"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90129-3"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.13.8.5057"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.03.099"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203797"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00456-1"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209682200"},{"issue":"1","key":"e_1_2_5_20_1","first-page":"S103","article-title":". 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