{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:46:58Z","timestamp":1773402418821,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,11]],"date-time":"2007-01-11T00:00:00Z","timestamp":1168473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: To evaluate the effect of a thrombospondin 1 (TSP1)\u2010derived peptide on inflammation and angiogenesis in an animal model of erosive arthritis and to assess the relationship between TSP1 and connective tissue growth factor (CTGF) in the pathophysiology of rheumatoid arthritis. <jats:italic>Methods<\/jats:italic>: Erosive arthritis in Lewis rats was induced by peptidoglycan\u2010polysaccharide (PG\u2010PS). Animals were divided into four groups: (1) negative control and groups receiving, (2) no treatment, (3) treatment with a TSP1\u2010derived peptide, and (4) treatment with a scrambled peptide. Samples obtained from ankle joint, spleen and liver were studied using histology, histomorphometry, immunohistochemistry and RT\u2010PCR. <jats:italic>Results<\/jats:italic>: Histological data indicated that the TSP1\u2010derived peptide treatment decreased neovascularization, leukocyte infiltration and thickening of the synovial lining of the joint, and reduced granuloma formation in the spleen and liver when compared to control groups. Higher concentrations of CTGF and TSP1 proteins were observed in the affected areas of animals which did not receive TSP1\u2010derived peptide treatment. Also, immunofluorescence and RT\u2010PCR analyses showed an increase in CTGF protein expression and regulation, respectively, in the tissues of untreated animals when compared to the TSP1\u2010derived peptide treated animals. By immunofluorescence, TSP1 expression was decreased in the TSP1\u2010derived peptide treated animals. Moreover, macrophage\/monocyte\u2010specific staining revealed a decrease in cell infiltration in the articular tissue of the TSP1\u2010derived peptide treated animals. <jats:italic>Conclusion<\/jats:italic>: Both inflammation and angiogenesis were decreased after TSP1\u2010derived peptide treatment indicating a potential pathway by which TSP1 interaction with neutrophils induces CTGF in RA affected tissues. J. Cell. Physiol. 211: 504\u2013512, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.20958","type":"journal-article","created":{"date-parts":[[2007,1,11]],"date-time":"2007-01-11T20:52:55Z","timestamp":1168548775000},"page":"504-512","source":"Crossref","is-referenced-by-count":30,"title":["Amelioration of inflammation, angiogenesis and CTGF expression in an arthritis model by a TSP1\u2010derived peptide treatment"],"prefix":"10.1002","volume":"211","author":[{"given":"Mario C.","family":"Rico","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian L.","family":"Castaneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne M.","family":"Manns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey 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