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However, several important issues remain unclear regarding this new observation, especially the difference between DOR and other opioid receptors in the stabilization of K<jats:sup>+<\/jats:sup> homeostasis and the underlying mechanism. In this study, we asked whether DOR is different from \u00b5\u2010opioid receptors (MOR) in stabilizing K<jats:sup>+<\/jats:sup> homeostasis and which membrane channel(s) is critically involved in the DOR effect. The main findings are that (1) similar to DADLE (10 \u00b5M), H\u2010Dmt\u2010Tic\u2010NH\u2010CH (CH<jats:sub>2<\/jats:sub>\uf8ffCOOH)\u2010Bid (1\u201310 \u00b5M), a more specific and potent DOR agonist significantly attenuated anoxic K<jats:sup>+<\/jats:sup> derangement in cortical slice; (2) [D\u2010Ala<jats:sup>2<\/jats:sup>, N\u2010Me\u2010Phe<jats:sup>4<\/jats:sup>, glycinol<jats:sup>5<\/jats:sup>]\u2010enkephalin (DAGO; 10 \u00b5M), a MOR agonist, did not produce any appreciable change in anoxic disruption of K<jats:sup>+<\/jats:sup> homeostasis; (3) absence of Ca<jats:sup>2+<\/jats:sup> greatly attenuated anoxic K<jats:sup>+<\/jats:sup> derangement; (4) inhibition of Ca<jats:sup>2+<\/jats:sup>\u2010activated K<jats:sup>+<\/jats:sup> (BK) channels with paxilline (10 \u00b5M) reduced anoxic K<jats:sup>+<\/jats:sup> derangement; (5) DADLE (10 \u00b5M) could not further reduce anoxic K<jats:sup>+<\/jats:sup> derangement in the Ca<jats:sup>2+<\/jats:sup>\u2010free perfused slices or in the presence of paxilline; and (6) glybenclamide (20 \u00b5M), a K<jats:sub>ATP<\/jats:sub> channel blocker, decreased anoxia\u2010induced K<jats:sup>+<\/jats:sup> derangement, but DADLE (10 \u00b5M) could further attenuate anoxic K<jats:sup>+<\/jats:sup> derangement in the glybenclamide\u2010perfused slices. These data suggest that DOR, but not MOR, activation is protective against anoxic K<jats:sup>+<\/jats:sup> derangement in the cortex, at least partially via an inhibition of hypoxia\u2010induced increase in Ca<jats:sup>2+<\/jats:sup> entry\u2010BK channel activity. J. Cell. Physiol. 212: 60\u201367, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.21000","type":"journal-article","created":{"date-parts":[[2007,3,20]],"date-time":"2007-03-20T14:32:44Z","timestamp":1174401164000},"page":"60-67","source":"Crossref","is-referenced-by-count":70,"title":["\u03b4\u2010, but not \u00b5\u2010, opioid receptor stabilizes K<sup>+<\/sup> homeostasis by reducing Ca<sup>2+<\/sup> influx in the cortex during acute hypoxia"],"prefix":"10.1002","volume":"212","author":[{"given":"Dongman","family":"Chao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alia","family":"Bazzy\u2010Asaad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Balboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-19-08337.1999"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.2.753"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90153-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2005.06.016"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm020336e"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.01106"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01535-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03934.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.06.003"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2741\/1490"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1016\/S0021-9258(17)30115-1","article-title":"Multiple opiate receptors. 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