{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:30:06Z","timestamp":1767839406021,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T00:00:00Z","timestamp":1173312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IL\u20101beta and stretch increase uterine smooth muscle cell (USMC) prostaglandin H synthase 2 (PGHS\u20102) and interleukin (IL)\u20108 mRNA expression in a mitogen\u2010activated protein kinase (MAPK) dependent mechanism. We have tested our hypothesis that stretch and IL\u20101beta activate different components of the MAPK cascade in USMC and investigated the effects of specific MAPK inhibitors on these components. Further, we have used a Jun N\u2010terminal kinase (JNK) and p38 activator, anisomycin, to compare the effect of differential MAPK activation on the expression of PGHS\u20102, IL\u20108 and oxytocin receptor (OTR) mRNA with that seen in response to stretch and IL\u20101beta. Stretch, IL\u20101beta and anisomycin activated similar components of the MAPK cascade and specific inhibitors of MAPK altered phosphorylation of MAPK and downstream cascade components as expected. Expression of OTR mRNA was increased by stretch and anisomycin in a MAPK\u2010independent manner. All three stimuli increased PGHS\u20102 and IL\u20108 mRNA expression in a MAPK\u2010dependent manner, but while the MAPK inhibitors reduced the IL\u20101beta\u2010induced activation of activating transcription factor (ATF)\u20102, liver activating protein (LAP) and c\u2010jun, the stretch\u2010induced increase in LAP was unaffected by MAPK\u2010inhibition and only JNK inhibition appeared to reduce c\u2010jun activation. These observations show that stretch, IL\u20101beta and anisomycin activate the same components of the MAPK cascade, but differentially activate LAP and liver inhibitory protein (LIP) perhaps accounting for the increase in OTR by stretch and anisomycin but not IL\u20101beta observed in this study. J. Cell. Physiol. 212: 195\u2013206, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.21019","type":"journal-article","created":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T21:35:35Z","timestamp":1173389735000},"page":"195-206","source":"Crossref","is-referenced-by-count":15,"title":["Stretch and interleukin 1 beta: Pro\u2010labour factors with similar mitogen\u2010activated protein kinase effects but differential patterns of transcription factor activation and gene expression"],"prefix":"10.1002","volume":"212","author":[{"given":"S.R.","family":"Sooranna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Engineer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.R.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.R.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Imperial College Parturition Research Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.14.6450-6459.2001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0608"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.11.7352"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/S0022-2275(20)34908-7","article-title":"Critical role of p42\/44(MAPK) activation in anisomycin and hepatocyte growth factor\u2010induced LDL receptor expression: activation of Raf\u20101\/Mek\u20101\/p42\/44(MAPK) cascade alone is sufficient to induce LDL receptor expression","volume":"40","author":"Dhawan P","year":"1999","journal-title":"J Lipid Res"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00649-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-5576(01)00142-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.1034"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.12.032"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212777200"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00031.2003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00290.2002"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00042.2004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod67.1.240"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3180247"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00607.2001"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705345"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsgi.2004.11.008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod59.5.1055"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod56.1.200"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20020508"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.8755-8920.2000.430204.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00601.2001"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-5576(98)00030-6"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.4.1380"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.122415"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah021"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1390"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.274.4.E634"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0277"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2649"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.12.5712"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.21019","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.21019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T22:16:22Z","timestamp":1697148982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.21019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,26]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["10.1002\/jcp.21019"],"URL":"https:\/\/doi.org\/10.1002\/jcp.21019","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,26]]}}}