{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:13:51Z","timestamp":1759580031464},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,5,2]],"date-time":"2007-05-02T00:00:00Z","timestamp":1178064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Among 14 peripheral blood samples obtained from patients affected by B chronic lymphocytic leukemia (B\u2010CLL) at initial stages (Rai 0\u20131) of the disease, 6 showed intermediate\/high levels of Zap\u201070 while 8 displayed low\/absent levels of Zap\u201070. Although Zap\u201070<jats:sup>high<\/jats:sup> and Zap\u201070<jats:sup>low<\/jats:sup> B\u2010CLL samples displayed similar levels of surface death receptor TRAIL\u2010R2, recombinant TRAIL induced cytotoxicity only in a subset of Zap\u201070<jats:sup>low<\/jats:sup> B\u2010CLL samples while Zap\u201070<jats:sup>high<\/jats:sup> were completely resistant to TRAIL. The gene expression profiling was next analyzed in all B\u2010CLL samples treated with either chlorambucil or recombinant TRAIL. While chlorambucil up\u2010regulated the steady\u2010state mRNA levels of known p53 target genes, such as PUMA, Fas\/CD95 and MDM2 in all B\u2010CLL samples examined, it significantly down\u2010regulated survivin in Zap\u201070<jats:sup>low<\/jats:sup> but not in Zap\u201070<jats:sup>high<\/jats:sup>. On the other hand, recombinant TRAIL up\u2010regulated the expression of several cytokines (IL\u20101\u03b2, IL\u20101\u03b1, IL\u20108), which have been involved in promoting B\u2010CLL cell survival. In particular, TRAIL selectively up\u2010regulated IL\u20101\u03b2 in Zap\u201070<jats:sup>low<\/jats:sup> B\u2010CLL samples, while it markedly and selectively up\u2010regulated its own mRNA and that of cyclooxigenase\u20102 (COX\u20102) in Zap\u201070<jats:sup>high<\/jats:sup>. Taken together, our findings suggest that a significant expression of Zap\u201070 modulate the response of B\u2010CLL to TRAIL, which might represents an initial step in the pathogenesis of B\u2010CLL. J. Cell. Physiol. 213: 229\u2013236, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.21116","type":"journal-article","created":{"date-parts":[[2007,5,3]],"date-time":"2007-05-03T16:20:06Z","timestamp":1178209206000},"page":"229-236","source":"Crossref","is-referenced-by-count":8,"title":["Differential gene expression induction by TRAIL in B chronic lymphocytic leukemia (B\u2010CLL) cells showing high versus low levels of Zap\u201070"],"prefix":"10.1002","volume":"213","author":[{"given":"Paola","family":"Secchiero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"di Iasio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Gonelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Barbarotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Melloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Tiribelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Chiaruttini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Zauli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,2]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"4521","article-title":"Identification of interleukin 8 as an inhibitor of tumor necrosis factor\u2010related apoptosis\u2010inducing ligand\u2010induced apoptosis in the ovarian carcinoma cell line OVCAR3","volume":"63","author":"Abdollahi T","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403139"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.3.724-736.2002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0189"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1182\/blood.V87.10.4382.bloodjournal87104382","article-title":"Interleukin\u20108 induces the accumulation of B\u2010cell chronic lymphocytic leukemia cells by prolonged survival in an autocrine fashion","volume":"87","author":"Di Celle PF","year":"1996","journal-title":"Blood"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","unstructured":"GobessiS LaurentiL LongoPG SicaS LeoneG EfremovDG.2006. 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