{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:28:53Z","timestamp":1792250933063,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,7,9]],"date-time":"2007-07-09T00:00:00Z","timestamp":1183939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult mesenchymal stem cells (MSCs) can be isolated from bone marrow or marrow aspirates and because they are culture\u2010dish adherent, they can be expanded in culture while maintaining their multipotency. The MSCs have been used in preclinical models for tissue engineering of bone, cartilage, muscle, marrow stroma, tendon, fat, and other connective tissues. These tissue\u2010engineered materials show considerable promise for use in rebuilding damaged or diseased mesenchymal tissues. Unanticipated is the realization that the MSCs secrete a large spectrum of bioactive molecules. These molecules are immunosuppressive, especially for T\u2010cells and, thus, allogeneic MSCs can be considered for therapeutic use. In this context, the secreted bioactive molecules provide a regenerative microenvironment for a variety of injured adult tissues to limit the area of damage and to mount a self\u2010regulated regenerative response. This regenerative microenvironment is referred to as trophic activity and, therefore, MSCs appear to be valuable mediators for tissue repair and regeneration. The natural titers of MSCs that are drawn to sites of tissue injury can be augmented by allogeneic MSCs delivered via the bloodstream. Indeed, human clinical trials are now under way to use allogeneic MSCs for treatment of myocardial infarcts, graft\u2010versus\u2010host disease, Crohn's Disease, cartilage and meniscus repair, stroke, and spinal cord injury. This review summarizes the biological basis for the in vivo functioning of MSCs through development and aging. J. Cell. Physiol. 213: 341\u2013347, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.21200","type":"journal-article","created":{"date-parts":[[2007,7,9]],"date-time":"2007-07-09T15:48:12Z","timestamp":1183996092000},"page":"341-347","source":"Crossref","is-referenced-by-count":1631,"title":["Adult mesenchymal stem cells for tissue engineering versus regenerative medicine"],"prefix":"10.1002","volume":"213","author":[{"given":"Arnold I.","family":"Caplan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1559"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14232-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-006-9212-x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.6013"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2921"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.2106\/00004623-199807000-00007","article-title":"The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects","volume":"80","author":"Bruder SP","year":"1998","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_11_8_1","first-page":"157","article-title":"Cell delivery and tissue regeneration","author":"Caplan AI","year":"1989","journal-title":"J Control Release"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090504"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.1198"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6348946"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/096368979200100106"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(97)00170-1"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(00)00635-4"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000144457.55518.E5"},{"key":"e_1_2_11_16_1","unstructured":"HarmanRJ CowlesB OravaC.2006.A retrospective review of 52 cases of suspensory ligament injury in sport horses treated with adipose\u2010derived stem and regenerative cells."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(92)90363-2"},{"key":"e_1_2_11_18_1","first-page":"79","volume-title":"Diminution of the number of mesenchymal stem cells as a cause for skeletal aging","author":"Haynesworth SE","year":"1994"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199603)166:3<585::AID-JCP13>3.0.CO;2-6"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1664"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.1997.3.173"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2004-0021"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-006-9029-9"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00100-X"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.2.307"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(20000305)49:3<328::AID-JBM5>3.0.CO;2-Q"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.014"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00573.x"},{"key":"e_1_2_11_29_1","first-page":"557","article-title":"Ex vivo expansion and subsequent infusion of human bone marrow\u2010derived stromal progenitor cells (mesenchymal progenitor cells): Implications for therapeutic use","volume":"16","author":"Lazarus HM","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.02.001"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.5.1085"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080341"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02724045"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1037>3.0.CO;2-7"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20126"},{"key":"e_1_2_11_36_1","first-page":"367","volume-title":"Bone formation and repair","author":"Liebergall M","year":"1994"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704400"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02932"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11365"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(1999)48:6<913::AID-JBM22>3.0.CO;2-0"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820271107"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.11.055"},{"key":"e_1_2_11_43_1","article-title":"Lineage of osteogenic cells and their relationship to the stromal system","author":"Owen M","year":"1985","journal-title":"Bone Miner Res"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.03.030"},{"key":"e_1_2_11_45_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittinger MF","year":"1999","journal-title":"Science"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200108150"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0293"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03517-8"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.4.696"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.1.55.55"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100180515"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2004.12.016"},{"key":"e_1_2_11_53_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2106\/00004623-200300002-00012","article-title":"Phenotypic plasticity of human articular chondrocytes","volume":"85","author":"Tallheden T","year":"2003","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1349.006"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00208-9"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1089\/107632701300062859"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.21200","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.21200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T17:55:53Z","timestamp":1697651753000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.21200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,9]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1002\/jcp.21200"],"URL":"https:\/\/doi.org\/10.1002\/jcp.21200","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,9]]}}}