{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:05:35Z","timestamp":1791133535797,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,2,12]],"date-time":"2008-02-12T00:00:00Z","timestamp":1202774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have previously found progressive diabetic nephropathy in inducible cAMP early repressor (ICER I\u03b3) transgenic (Tg) mice. The ICER I\u03b3 Tg mouse is an interesting model of sustained hyperglycemia due to its low production of insulin and insulin\u2010producing \u03b2 cells. Here in a longitudinal study we further analyzed diabetic nephropathy and structural and functional alterations in other organs, comparing our model with streptozotocin (STZ)\u2010diabetic model mice. The high\u2010dose STZ\u2010diabetic model showed marked variation in blood glucose levels and severe toxicity of STZ in the liver and kidney. The low\u2010dose STZ\u2010diabetic model showed less toxicity, but the survival rate was very low. STZ\u2010diabetic mice had much more variation of glomerular hypertrophy and sclerosis. Furthermore, non\u2010specific toxicity of STZ or insulin injections to maintain optimal blood glucose levels might have another effect upon the diabetic renal changes. In contrast, ICER I\u03b3 Tg mice exhibited a stable and progressive phenotype of diabetic kidney disease solely due to chronic hyperglycemia without other modulating factors. Thus, ICER I\u03b3 Tg mouse has advantages for examining diabetic renal disease, and offers unique and very different perspectives compared to STZ model. J. Cell. Physiol. 215: 383\u2013391, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.21316","type":"journal-article","created":{"date-parts":[[2008,2,12]],"date-time":"2008-02-12T16:46:19Z","timestamp":1202834779000},"page":"383-391","source":"Crossref","is-referenced-by-count":35,"title":["A model for diabetic nephropathy: Advantages of the inducible cAMP early repressor transgenic mouse over the streptozotocin\u2010induced diabetic mouse"],"prefix":"10.1002","volume":"215","author":[{"given":"Akari","family":"Inada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kanamori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Akashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon C.","family":"Weir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Fukatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0240297"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004080648"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnh.0000222687.75055.eb"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-861370"},{"key":"e_1_2_6_6_1","first-page":"F100","article-title":"Streptozotocin\u2010induced renal hemodynamic changes in isogenic Lewis rats: A kidney transplant study","volume":"264","author":"Churchill P","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_6_7_1","first-page":"204","article-title":"Glomerular lesions in nonobese diabetic mouse: Before and after the onset of hyperglycemia","volume":"63","author":"Doi T","year":"1990","journal-title":"Lab Invest"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90503-Q"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(02)00014-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9833"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.30.21095"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.7.2831-2841.2004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.02.046"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62978-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.159.83"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00007.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-126-32401"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00040.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.8.8.8181671"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.139.4.793"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002389"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.180605"},{"key":"e_1_2_6_23_1","first-page":"470","article-title":"Streptozotocin\u2010induced pancreatic insulitis in mice. 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