{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:43Z","timestamp":1772118703287,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T00:00:00Z","timestamp":1196208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The epithelium\u2010specific ETS (ESE)\u20101 transcription factor is induced in chondrocytes by interleukin\u20101\u03b2 (IL\u20101\u03b2). We reported previously that early activation of EGR\u20101 by IL\u20101\u03b2 results in suppression of the proximal\n                    <jats:italic>COL2A1<\/jats:italic>\n                    promoter activity by displacement of Sp1 from GC boxes. Here we report that ESE\u20101 is a potent transcriptional suppressor of\n                    <jats:italic>COL2A1<\/jats:italic>\n                    promoter activity in chondrocytes and accounts for the sustained, NF\u2010\u03baB\u2010dependent inhibition by IL\u20101\u03b2. Of the ETS factors tested, this response was specific to ESE\u20101, since ESE\u20103, which was also induced by IL\u20101\u03b2, suppressed\n                    <jats:italic>COL2A1<\/jats:italic>\n                    promoter activity only weakly. In contrast, overexpression of ETS\u20101 increased\n                    <jats:italic>COL2A1<\/jats:italic>\n                    promoter activity and blocked the inhibition by IL\u20101\u03b2. These responses to ESE\u20101 and ETS\u20101 were confirmed using siRNA\u2010ESE1 and siRNA\u2010ETS1. In transient cotransfections, the inhibitory responses to ESE\u20101 and IL\u20101\u03b2 colocalized in the \u2212577\/\u2212132 bp promoter region, ESE\u20101 bound specifically to tandem ETS sites at \u2212403\/\u2212381 bp, and IL\u20101\u2010induced binding of ESE\u20101 to the\n                    <jats:italic>COL2A1<\/jats:italic>\n                    promoter was confirmed in vivo by ChIP. Our results indicate that ESE\u20101 serves a potent repressor function by interacting with at least two sites in the\n                    <jats:italic>COL2A1<\/jats:italic>\n                    promoter. However, the endogenous response may depend upon the balance of other ETS factors such as ETS\u20101, and other IL\u20101\u2010induced factors, including EGR\u20101 at any given time. Intracellular ESE\u20101 staining in chondrocytes in cartilage from patients with osteoarthritis (OA), but not in normal cartilage, further suggests a fundamental role for ESE\u20101 in cartilage degeneration and suppression of repair. J. Cell. Physiol. 215: 562\u2013573, 2008. \u00a9 2007 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/jcp.21338","type":"journal-article","created":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T17:17:06Z","timestamp":1196270226000},"page":"562-573","source":"Crossref","is-referenced-by-count":48,"title":["ESE\u20101 is a potent repressor of type II collagen gene (\n                    <i>COL2A1<\/i>\n                    ) transcription in human chondrocytes"],"prefix":"10.1002","volume":"215","author":[{"given":"Haibing","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lujian","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Osaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosei","family":"Ijiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaneyuki","family":"Tsuchimochi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Otero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bob 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