{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:12:36Z","timestamp":1790863956320,"version":"4.1.0"},"reference-count":122,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,2,4]],"date-time":"2008-02-04T00:00:00Z","timestamp":1202083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Wnt signalling has an essential role in regulating bone formation and remodelling during embryonic development and throughout postnatal and adult life. Specifically, Wnt signalling regulates bone formation by controlling embryonic cartilage development and postnatal chondrogenesis, osteoblastogenesis, osteoclastogenesis, endochondral bone formation, and bone remodelling. Abnormalities in the function of Wnt genes give rise to or contribute to the development of several pathological bone conditions, including abnormal bone mass, osteosarcomas and bone loss in multiple myeloma. Furthermore, Wnt signalling is activated during bone fracture repair and plays a crucial role in regulating bone regeneration. J. Cell. Physiol. 215: 578\u2013587, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.21342","type":"journal-article","created":{"date-parts":[[2008,2,4]],"date-time":"2008-02-04T17:52:09Z","timestamp":1202147529000},"page":"578-587","source":"Crossref","is-referenced-by-count":132,"title":["Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair"],"prefix":"10.1002","volume":"215","author":[{"given":"Carmen E.","family":"Macsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce K.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory J.","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/497706"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.12.4946-4955.2005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.01.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20905"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.09.023"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.10.3624"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.03.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02951-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-007-0006-0"},{"key":"e_1_2_7_11_1","first-page":"358","article-title":"Downregulation of SOST\/sclerostin by PTH: A novel mechanism of hormonal control of bone formation mediated by osteocytes","volume":"6","author":"Bellido T","year":"2006","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408742102"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.11.008"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0498"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20284"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013444"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02826"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040249"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602700200"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0606365"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1665"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2006-0346"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.03.016"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.01.016"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/107632704323061753"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(93)90034-U"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02354-05"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1538"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20609"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20466"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.02.014"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2007.71"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00536.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00973"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63348-2"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1235"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.02.017"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00571-2"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300373200"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/jbiol22"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203171200"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050101"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.040807"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.02.013"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11677"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501900200"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.2741\/2296"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.07.067"},{"key":"e_1_2_7_49_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0030-5898(20)31561-3","article-title":"Growth plate physiology and pathology","volume":"21","author":"Iannotti JP","year":"1990","journal-title":"Orthop Clin North Am"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00416.2006"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.05.075"},{"key":"e_1_2_7_52_1","first-page":"3495","article-title":"Aberrant expression of the growth factor Wnt\u20105A in human malignancy","volume":"55","author":"Iozzo RV","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00674"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.01.007"},{"key":"e_1_2_7_55_1","first-page":"135","article-title":"The high bone mass family\u2013the role of Wnt\/Lrp5 signaling in the regulation of bone mass","volume":"4","author":"Johnson ML","year":"2004","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00157-0"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200201089"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-169x.1999.00402.x"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00623"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.12.8536"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2006.11.001"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2005.01.004"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28551"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1346.002"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.7.2.169"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2004.10.008"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukaryotGeneExpr.v14.i12.10"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.12.1971"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1086\/338450"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.20.010403.113126"},{"key":"e_1_2_7_71_1","first-page":"357","article-title":"Wnt signaling is involved in the inhibitory action of sclerostin on BMP\u2010stimulated bone formation","volume":"6","author":"Lowik CW","year":"2006","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_7_72_1","first-page":"S114","article-title":"Sclerostin, a natural inhibitor of bone formation, fulfils criteria of an ideal drug target for osteoporosis","volume":"40","author":"Lowik C","year":"2007","journal-title":"Bone"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407810200"},{"key":"e_1_2_7_74_1","first-page":"s54","article-title":"Expression of Wnt signalling molecules at the injured growth plate cartilage in young rats","volume":"80","author":"Macsai CE","year":"2007","journal-title":"Calcif Tissue Int"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1136370"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(02)01106-X"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature756"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.52.1"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060719"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508324200"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/438747a"},{"key":"e_1_2_7_82_1","first-page":"S44","article-title":"Administration of sclerostin monoclonal antibodies to female Cynomologous monkeys results in increased bone formation, bone mineral density, and bone strength","volume":"21","author":"Ominsky M","year":"2006","journal-title":"J Bone Miner Res"},{"key":"e_1_2_7_83_1","first-page":"S44","article-title":"Sclerostin monoclonal antibody treatment increases bone strength in aged osteopenic ovariectomized rats","volume":"21","author":"Ominsky M","year":"2006","journal-title":"J Bone Miner Res"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4940"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2370"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.04.101"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(06)76001-X"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-15"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1080\/08977190410001720860"},{"key":"e_1_2_7_90_1","first-page":"S144","article-title":"Dkk1 blocks Wnt\u2010Induced osteoprotegrin production in osteoblast progenitors in multiple myeloma","volume":"40","author":"Qiang Y","year":"2007","journal-title":"Bone"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5481.950"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.04.107"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000012303.37971.DA"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609509200"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00290-1"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504308200"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.050574297"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200104)44:4<772::AID-ANR133>3.0.CO;2-L"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-007-0005-1"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0042"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-007-9096-3"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02883"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01570"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414275200"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030847"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0784fje"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.02.001"},{"key":"e_1_2_7_108_1","first-page":"15","article-title":"Bone morphogenetic proteins and their antagonists: The sclerostin paradigm","volume":"28","author":"van Bezooijen RL","year":"2005","journal-title":"J Endocrinol Invest"},{"key":"e_1_2_7_109_1","doi-asserted-by":"crossref","unstructured":"van BezooijenRL ten DijkeP PapapoulosSE LowikCW.2005b.SOST\/sclerostin an osteocyte\u2010derived negative regulator of bone formation. Cytokine Growth Factor Rev.16:319\u2013327.","DOI":"10.1016\/j.cytogfr.2005.02.005"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.061002"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050614"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2005.11.007"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2004.06.044"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg599"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400524200"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2006-0049"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2003.08.003"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00216-8"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00324"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00282-9"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.12.008"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060410"},{"key":"e_1_2_7_123_1","first-page":"S147","article-title":"B\u2010catenin signaling is required for postnatal cartilage development","volume":"40","author":"Zhu M","year":"2007","journal-title":"Bone"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.21342","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.21342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T04:04:38Z","timestamp":1697083478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.21342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,4]]},"references-count":122,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1002\/jcp.21342"],"URL":"https:\/\/doi.org\/10.1002\/jcp.21342","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,4]]}}}