{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:40:44Z","timestamp":1789422044351,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,1,18]],"date-time":"2008-01-18T00:00:00Z","timestamp":1200614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heat shock protein B (HspB) is one of the dominant proteins recognized by most <jats:italic>Helicobacter pylori<\/jats:italic>\u2010infected persons and is being considered as potential candidates for subunit vaccines. In the present study we describe the generation of an antibody against HspB and its use in immunohistochemical assays on gastric biopsies. We have demonstrated that our rabbit polyclonal antibody against HspB did not recognize any protein in lysates from a lung human epithelial cell (H1299) line and did not cross\u2010react with the other members of human heat shock proteins. Secondly, we have observed that in gastric biopsies, HspB immunostaining was present inside the cytoplasm of human epithelial cells with a particular localization in the apical portion of gastric epithelial cells other than in the extracellular spaces among gastric cells of human stomach. Finally, we have demonstrated a cytoplasmic HspB immunostaining in groups of neoplastic cells of MALT lymphoma. In conclusion, our observations suggest a possible involvement of HspB in the pathogenesis of <jats:italic>H. pylori<\/jats:italic>\u2010related pathologies such as gastritis, ulcer and gastric cancer. J. Cell. Physiol. 216: 78\u201382, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.21376","type":"journal-article","created":{"date-parts":[[2008,1,18]],"date-time":"2008-01-18T17:46:17Z","timestamp":1200678377000},"page":"78-82","source":"Crossref","is-referenced-by-count":8,"title":["<i>Helicobacter pylori<\/i> heat shock protein B (HspB) localizes in vivo in the gastric mucosa and MALT lymphoma"],"prefix":"10.1002","volume":"216","author":[{"given":"Antonio","family":"De Luca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"De 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