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A major type II NKT subset has been shown to recognize a self\u2010glycolipid, sulfatide. Both subsets play important roles in autoimmune diseases, tumor surveillance, and infectious diseases. While type I NKT cells protect from tumor growth by enhancing tumor surveillance, type II NKT cells may suppress anti\u2010tumor immune responses. In a murine autoimmune hepatitis model, type I NKT cells contribute to pathogenesis, whereas activation of sulfatide\u2010reactive type II NKT cells protects from disease. Sulfatide\u2010mediated activation of type II NKT cells results in modification of dendritic cells and induction of anergy in type I NKT cells. Elucidation of this novel pathway of cross\u2010regulation among NKT cell subsets will provide tools for intervention in autoimmune diseases and for designing strategies for effective anti\u2010tumor immunity. J. Cell. Physiol. 218: 246\u2013250, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.21597","type":"journal-article","created":{"date-parts":[[2008,9,22]],"date-time":"2008-09-22T13:48:12Z","timestamp":1222091292000},"page":"246-250","source":"Crossref","is-referenced-by-count":69,"title":["Cross\u2010regulation between distinct natural killer T cell subsets influences immune response to self and foreign 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