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CAMVE potentiates TNF\u2010induced cell death as analyzed by cell viability assay and blocks inflammatory stimuli\u2010induced nuclear transcription factor kappaB (NF\u2010\u03baB) activation and NF\u2010\u03baB\u2010dependent genes expression. CAMVE\u2010mediated inhibition of NF\u2010\u03baB or induction of cell death is not cell type specific. CAMVE inhibits cell proliferation by inhibiting G1 to S phase progression. It suppresses TNF\u2010induced Bcl\u20102 expression and potentiates chemotherapeutic agents\u2010mediated cell death. CAMVE enhances intracellular free Ca<jats:sup>2+<\/jats:sup> and thereby activates calcineurin. Calcineurin, in turns, activates nuclear transcription factor NF\u2010AT and its dependent genes such as FasL, which induces cell death. The data demonstrate that CAMVE is one of the combinatorial products, which is able to inhibit NF\u2010\u03baB regulated genes and cell proliferation. The combinatorial synthesis of novel caffeic ester derivatives can be a useful approach to generate potent chemotherapeutic agents and designing CAMVE as potent therapeutic agent for combination therapy may be useful to treat tumors. J. Cell. Physiol. 218: 653\u2013662, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.21640","type":"journal-article","created":{"date-parts":[[2008,11,25]],"date-time":"2008-11-25T13:26:23Z","timestamp":1227619583000},"page":"653-662","source":"Crossref","is-referenced-by-count":16,"title":["Novel caffeic acid ester derivative induces apoptosis by expressing fasl and downregulating NF\u2010KappaB: Potentiation of cell death mediated by chemotherapeutic agents"],"prefix":"10.1002","volume":"218","author":[{"given":"Julie S.","family":"Bose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Gangan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swatantra K.","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil 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