{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:14Z","timestamp":1786978034027,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,6]],"date-time":"2009-02-06T00:00:00Z","timestamp":1233878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Growing evidence indicates that aldosterone is a potent mitogenic signal regulating genes involved in antiapoptosis, cell proliferation and growth. We investigated the role of endogenous aldosterone in renal development, cell proliferation and apoptosis, and mitogen\u2010activated protein kinase (MAPK) family expression. Newborn rats were treated with either spironolactone (200 mg\/kg\/d) in olive oil or only olive oil for 7 days. TUNEL assay and proliferating cell nuclear antigen (PCNA) stain were performed on kidney sections. Immunoblots, immunohistochemical (IHC) stain, and reverse transcriptase\u2010PCR for MAPKs were performed. PCNA\u2010positive proliferating cells decreased and apoptotic cells increased significantly with spironolactone (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). In the spironolactone\u2010treated group, c\u2010jun N\u2010terminal kinase (JNK)\u20102 expression increased, whereas extracellular signal regulated kinase (ERK)\u20102 and p38 expressions decreased in immunoblots (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05) and IHC stain. ERK\u20102 and p38 mRNA expressions increased in the spironolactone\u2010treated group (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). This study demonstrates that aldosterone blockade in the developing kidney decreases cellular proliferation, increases apoptosis, and modulates the expressions of JNK\u20102, ERK\u20102, and p38. Aldosterone possibly participates in renal development and MAPK family may serve as, in part, the signaling intermediate through the mineralocorticoid receptor (MR) in the developing kidney. J. Cell. Physiol. 219: 724\u2013733, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/jcp.21723","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T03:25:45Z","timestamp":1233977145000},"page":"724-733","source":"Crossref","is-referenced-by-count":18,"title":["Aldosterone regulates cellular turnover and mitogen\u2010activated protein kinase family expression in the neonatal rat kidney"],"prefix":"10.1002","volume":"219","author":[{"given":"Hyung Eun","family":"Yim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Hwan","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Sun","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Young","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Sook","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo 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