{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:48:47Z","timestamp":1791978527848,"version":"4.4.0"},"reference-count":63,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,5,26]],"date-time":"2009-05-26T00:00:00Z","timestamp":1243296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cation\u2010Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    cotransporters (CCCs) belong to a large family of proteins that includes 9 isoforms, two of which have still not been ascribed a transport function (CCC8 and CCC9) while the others are all known to promote Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u2010coupled Na\n                    <jats:sup>+<\/jats:sup>\n                    and\/or K\n                    <jats:sup>+<\/jats:sup>\n                    movement at the cell surface. The CCCs are also included in a larger family termed amino acid\u2010polyamine\u2010organocation carriers (APCs). In contrast to the CCCs, however, polyamine (PA) transporters have thus far been isolated from unicellular species exclusively and do not all belong to the APC family. In this work, we have found that a splice variant of CCC9 (CCC9a) promotes PA\u2010amino acid transport at the surface of HEK\u2010293 cells. We have also found that the influx of PAs in CCC9a\u2010expressing cells is inhibited by pentamidine as well as furosemide, and that it increases further in the presence of specific amino acids but not of Na\n                    <jats:sup>+<\/jats:sup>\n                    , K\n                    <jats:sup>+<\/jats:sup>\n                    , or Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    . Hence, a group of substrates that are directly transported by CCC9 and the molecular identity of a PA transport system in animal cells may have been uncovered for the first time. These findings are of special interest given that intracellular PAs play a key role in cell proliferation. J. Cell. Physiol. 220: 680\u2013689, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/jcp.21814","type":"journal-article","created":{"date-parts":[[2009,5,26]],"date-time":"2009-05-26T11:27:08Z","timestamp":1243337228000},"page":"680-689","source":"Crossref","is-referenced-by-count":76,"title":["Molecular characterization of a human cation\u2010Cl\n                    <sup>\u2212<\/sup>\n                    cotransporter (SLC12A8A, CCC9A) that promotes polyamine and amino acid transport"],"prefix":"10.1002","volume":"220","author":[{"given":"Nikolas D.","family":"Daigle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel A.","family":"Carpentier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachelle","family":"Frenette\u2010Cotton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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