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Alteration in the ionized calcium concentration in the cytosol has been implicated in the initiation of secretion, contraction, and cell proliferation as well as the production of reactive oxygen species (ROS) has been correlates with normal cell proliferation through activation of growth\u2010related signaling pathways. In this study we evaluated in peripheral blood leukocytes from CML patients the role of the balance between intracellular calcium and oxidative stress in CML disease in order to identify possible therapeutic targets in patients affected by this pathology. Our results demonstrated that peripheral blood mononuclear cells derived from CML patients displayed decreased intracellular calcium [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> fluxes both after InsP<jats:sub>3<\/jats:sub> as well as ATP and ionomycin (IONO) administration. CML cells showed lower levels of superoxide dismutase (SOD) activity and significantly higher malondialdehyde levels (MDA) than peripheral blood mononuclear cells derived from control patients. Finally we showed that resveratrol is able to down\u2010regulate InsP3 and ATP effects on intracellular calcium [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> fluxes as well as the effects of ATP and IONO on oxidative stress in CML cells. J. Cell. Physiol. 224: 443\u2013453, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.22140","type":"journal-article","created":{"date-parts":[[2010,4,2]],"date-time":"2010-04-02T17:39:39Z","timestamp":1270229979000},"page":"443-453","source":"Crossref","is-referenced-by-count":31,"title":["Dysregulated calcium homeostasis and oxidative stress in chronic myeloid leukemia (CML) 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