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The stringent control of the MIC\u20101 expression, secretion, and functions involves complex regulatory mechanisms and the interplay of other growth factor signaling networks that control the cell behavior. The deregulation of MIC\u20101 expression and signaling pathways has been associated with diverse human diseases and cancer progression. The MIC\u20101 expression levels substantially increase in cancer cells, serum, and\/or cerebrospinal fluid during the progression of diverse human aggressive cancers, such as intracranial brain tumors, melanoma, and lung, gastrointestinal, pancreatic, colorectal, prostate, and breast epithelial cancers. Of clinical interest, an enhanced MIC\u20101 expression has been positively correlated with poor prognosis and patient survival. Secreted MIC\u20101 cytokine, like the TGF\u2010\u03b2 prototypic member of the superfamily, may provide pleiotropic roles in the early and late stages of carcinogenesis. In particular, MIC\u20101 may contribute to the proliferation, migration, invasion, metastases, and treatment resistance of cancer cells as well as tumor\u2010induced anorexia and weight loss in the late stages of cancer. Thus, secreted MIC\u20101 cytokine constitutes a new potential biomarker and therapeutic target of great clinical interest for the development of novel diagnostic and prognostic methods and\/or cancer treatment against numerous metastatic, recurrent, and lethal cancers. J. Cell. Physiol. 224: 626\u2013635, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.22196","type":"journal-article","created":{"date-parts":[[2010,5,12]],"date-time":"2010-05-12T18:34:48Z","timestamp":1273689288000},"page":"626-635","source":"Crossref","is-referenced-by-count":189,"title":["Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine\u20101 in cancer"],"prefix":"10.1002","volume":"224","author":[{"given":"Murielle","family":"Mimeault","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surinder 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