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Sumoylation provides either a stimulatory or an inhibitory signal for proliferation and for transcription, but the molecular mechanisms by which SUMO\u20101 achieves such versatility of effects are incompletely defined. The tumor suppressor and transcription regulator p53 is a relevant SUMO\u20101 target. Particularly, the C\u2010terminal tail of p53 undergoes both sumoylation and acetylation. While the effects of sumoylation are still controversial, acetylation modifies p53 interaction with chromatin embedded promoters, and enforces p53 apoptotic activity. In this study, we show that the N\u2010terminal region of SUMO\u20101 might functionally mimic this activity of the p53 C\u2010terminal tail. We found that this SUMO\u20101 domain possesses similarity with the C\u2010terminal acetylable p53 tail as well as with acetylable domains of other transcription factors. SUMO\u20101 is, indeed, acetylated when conjugated to its substrates and to p53. In the acetylable form SUMO\u20101 tunes the p53 response by modifying p53 transcriptional program, by promoting binding onto selected promoters and by favoring apoptosis. By contrast, when non\u2010acetylable, SUMO\u20101 enforces cell\u2010cycle arrest and p53 binding to a different sets of genes. These data demonstrate for the first time that SUMO\u20101, a post\u2010translational modification is, in turn, modified by acetylation. Further, they imply that the pleiotropy of effects by which SUMO\u20101 influences various cellular outcomes and the activity of p53 depends upon its acetylation state. J. Cell. Physiol. 225: 371\u2013384, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.22224","type":"journal-article","created":{"date-parts":[[2010,5,6]],"date-time":"2010-05-06T17:38:19Z","timestamp":1273167499000},"page":"371-384","source":"Crossref","is-referenced-by-count":19,"title":["Functional mimicry of the acetylated C\u2010terminal tail of p53 by a SUMO\u20101 acetylated domain, SAD"],"prefix":"10.1002","volume":"225","author":[{"given":"Amrita","family":"Cheema","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad 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