{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:28:57Z","timestamp":1791268137024,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,7,15]],"date-time":"2010-07-15T00:00:00Z","timestamp":1279152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Activation of the receptor activator of NF\u2010\u03baB (RANK) is a crucial step in osteoclastogenesis. Loss\u2010 and gain\u2010of\u2010function mutations in the <jats:italic>Rank<\/jats:italic> gene cause, respectively, osteopetrosis and several forms of extensive osteolysis. Tooth and alveolar bone alterations are associated with these pathologies but remain to be better characterized. The aim of the present study was to establish the tooth and alveolar bone phenotype of a transgenic mouse model of RANK over\u2010expression in osteoclast precursors. Early tooth eruption and accelerated tooth root elongation were observed subsequent to an increase in osteoclast numbers surrounding the tooth. The final root length appeared not to be affected by RANK over\u2010expression, but a significant reduction in root diameter occurred in both control and root\u2010morphogenesis\u2010defective <jats:italic>Msx2<\/jats:italic> null mutant mice. These results indicate that root length is independent of the surrounding bone resorption activity. In contrast, root diameter is sensitive to the activity of alveolar bone osteoclasts. These data suggest that early eruption and thin root are phenotypic features that could be associated with extensive osteolytic pathologies. J. Cell. Physiol. 226: 74\u201385, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.22305","type":"journal-article","created":{"date-parts":[[2010,7,15]],"date-time":"2010-07-15T20:00:08Z","timestamp":1279224008000},"page":"74-85","source":"Crossref","is-referenced-by-count":50,"title":["Bone resorption control of tooth eruption and root morphogenesis: Involvement of the receptor activator of NF\u2010\u03baB (RANK)"],"prefix":"10.1002","volume":"226","author":[{"given":"Beatriz","family":"Castaneda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohann","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Jacques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Hess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Wong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Blin\u2010Wakkach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Berdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"L\u00e9zot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.07.023"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.2.1103"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00473.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21383"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.12.2095"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.18.2119"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.18.2412"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.132.4.541"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.06.015"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00247.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2005.02.007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2004.11.016"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-008-0655-z"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/3.2.359"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/71667"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.2.376"},{"key":"e_1_2_7_18_1","first-page":"207","article-title":"Distribution of the epithelial rests of Malassez and their relationship to blood vessels of the periodontal ligament during rat tooth development","volume":"19","author":"Kat PS","year":"2003","journal-title":"Aust Orthod J"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-007-0397-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modgep.2006.10.001"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200294797"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/16852"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.8.1907.1907"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.3.1047"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80290-1"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01877"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540004800213"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21448"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22095"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1566"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2005.00245.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22047"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(90)90145-I"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1065-6995(03)00075-1"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500506"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.8.1381"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008200390181753"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300311"},{"key":"e_1_2_7_39_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1302\/0301-620X.70B2.3346299","article-title":"Familial expansile osteolysis: A new dysplasia","volume":"70","author":"Osterberg PH","year":"1988","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcbr.2000.0205"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2076"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-002-0276-3"},{"key":"e_1_2_7_43_1","first-page":"532","volume-title":"Oral histology. Development, structure, and function","author":"Ten Cate AR","year":"1994"},{"key":"e_1_2_7_44_1","first-page":"1711","article-title":"Monocyte recruitment and expression of monocyte chemoattractant protein\u20101 are developmentally regulated in remodeling bone in the mouse","volume":"150","author":"Volejnikova S","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_7_45_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00003086-198911000-00043","article-title":"Familial expansile osteolysis","volume":"248","author":"Wallace RG","year":"1989","journal-title":"Clin Orthop Rel Res"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1346.016"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.1.26"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.12.2330"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013096"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2009.01439.x"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345890680021001"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2006.00406.x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300906"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200305"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.2006.00150.x"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3597"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.3.5837"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10404"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.22305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.22305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T13:39:15Z","timestamp":1696858755000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.22305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,26]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1002\/jcp.22305"],"URL":"https:\/\/doi.org\/10.1002\/jcp.22305","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,26]]}}}