{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:36:48Z","timestamp":1789137408160,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,1,25]],"date-time":"2011-01-25T00:00:00Z","timestamp":1295913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Store\u2010operated calcium entry (SOCE) is essential for many cellular processes. In this study, we investigated modulation of SOCE by tyrosine phosphorylation in rat epididymal basal cells. The intracellular Ca<jats:sup>2+<\/jats:sup>([Ca<jats:sup>2+<\/jats:sup>]i) measurement showed that SOCE occurred in rat epididymal basal cells by pretreating the cells with thapsigargin (Tg), the inhibitor of sarco\u2010endoplasmic reticulum Ca<jats:sup>2+<\/jats:sup>\u2010ATPase. To identify the role of Ca<jats:sup>2+<\/jats:sup> channels in this response, we examined the effects of transient receptor potential canonical channel blockers 2\u2010aminoethoxydiphenyl borate (2\u2010APB), 1\u2010[\u03b2\u2010[3\u2010(4\u2010methoxyphenyl)pro\u2010poxy]\u20104\u2010methoxyphenethyl]\u20101H\u2010imidazole hydrochloride(SKF96365), Gd<jats:sup>3+<\/jats:sup>, and non\u2010selective cation channel blocker Ni<jats:sup>2+<\/jats:sup> respectively on SOCE and found that these blockers could inhibit the Ca<jats:sup>2+<\/jats:sup> influx to different extent. Furthermore, we studied the regulation of SOCE by tyrosine kinase pathway. The inhibitor of tyrosine kinase genistein remarkably suppressed the SOCE response, whereas sodium orthovanadate, the inhibitor of tyrosine phosphatase, greatly enhanced it. The results suggest that tyrosine kinase pathway plays a significant role in the initiation of SOCE and positively modulates SOCE in epididymal basal cells. J. Cell. Physiol. 226: 1069\u20131073, 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.22429","type":"journal-article","created":{"date-parts":[[2010,9,20]],"date-time":"2010-09-20T14:46:03Z","timestamp":1284993963000},"page":"1069-1073","source":"Crossref","is-referenced-by-count":10,"title":["Tyrosine phosphorylation modulates store\u2010operated calcium entry in cultured rat epididymal basal cells"],"prefix":"10.1002","volume":"226","author":[{"given":"Wu\u2010Lin","family":"Zuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Yang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie\u2010Hong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye\u2010Chun","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.K.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Liang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1765"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2008.03.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.11041"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C800008200"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200409205"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739680600930354"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/35077544"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-214-44097"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.106.052316"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.068346"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800906778194603"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1101-e255"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(01)00438-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2006.12.004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406364200"},{"key":"e_1_2_6_17_1","first-page":"81","volume-title":"The epididymis: From molecules to clinical practice","author":"Hermo L","year":"2001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092390409"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2006.83"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2003.10.077"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1352"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.01.018"},{"issue":"6","key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1016\/S0021-9258(17)41728-5","article-title":"Phosphorylation down\u2010regulates the store\u2010operated Ca2+ entry pathway of human neutrophils","volume":"269","author":"Montero M","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003606200"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/216816a0"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00057.2003"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.2.201"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4160(03)00024-1"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012174"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.809ad.x"},{"key":"e_1_2_6_31_1","first-page":"119","volume-title":"The epididymis: From molecules to clinical practice","author":"Wong PY","year":"2001"},{"key":"e_1_2_6_32_1","first-page":"456","volume-title":"Exocrine physiology: Basic theories and clinical aspects","author":"Wu LJ","year":"2002"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod50.4.917"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00591-1"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.22429","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.22429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T21:02:42Z","timestamp":1697662962000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.22429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,25]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1002\/jcp.22429"],"URL":"https:\/\/doi.org\/10.1002\/jcp.22429","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,25]]}}}