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While substantial evidence indicates that HNK possesses anti\u2010inflammatory activity, its effect on dendritic cells (DCs) during the inflammatory reaction remains unclear. The present study investigates how HNK affects lipopolysaccharide (LPS)\u2010stimulated human monocyte\u2010derived DCs. Our experimental results show that HNK inhibits the inflammatory response of LPS\u2010induced DCs by (1) suppressing the expression of CD11c, CD40, CD80, CD83, CD86, and MHC\u2010II on LPS\u2010activated DCs, (2) reducing the production of TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106, and IL\u201012p70 but increasing the production of IL\u201010 and TGF\u2010\u03b21 by LPS\u2010activated DCs, (3) inhibiting the LPS\u2010induced DC\u2010elicited allogeneic T\u2010cell proliferation, and (4) shifting the LPS\u2010induced DC\u2010driven Th1 response toward a Th2 response. Further, our results show that HNK inhibits the phosphorylation levels of ERK1\/2, p38, JNK1\/2, IKK\u03b1, and I\u03baB\u03b1 in LPS\u2010activated DCs. Collectively, the findings show that the anti\u2010inflammatory actions of HNK on LPS\u2010induced DCs are associated with the NF\u2010\u03baB and mitogen\u2010activated protein kinase (MAPK) signaling pathways. J. Cell. Physiol. 226: 2338\u20132349, 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.22576","type":"journal-article","created":{"date-parts":[[2010,12,9]],"date-time":"2010-12-09T13:27:39Z","timestamp":1291901259000},"page":"2338-2349","source":"Crossref","is-referenced-by-count":45,"title":["Honokiol inhibits LPS\u2010induced maturation and inflammatory response of human monocyte\u2010derived dendritic cells"],"prefix":"10.1002","volume":"226","author":[{"given":"Chia\u2010Yang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis 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