{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:20:25Z","timestamp":1767666025345},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,8,24]],"date-time":"2011-08-24T00:00:00Z","timestamp":1314144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Expression of IL\u201023, a heterodimeric cytokine involved in the induction of Th17 cells, is increased in human tumors. Although the endogenous IL\u201023 expression has been reported to promote tumor development and growth, the studies using local and systemic administration of IL\u201023 have shown that its application at the excessive amount induces antitumor immune responses. IL\u201023 is, today, considered the key driver of intestinal inflammation and its role in inflammatory responses is tissue\u2010specific. The aim of this study was to investigate the role of circulating levels of IL\u201023 in patients with resected colorectal cancer (CRC) before and after chemotherapy, respect to healthy controls. Twenty\u2010five patients were enrolled between June 2007 and January 2009, and followed through 2010. All patients underwent chemotherapy, mostly FOLFOX4. Twenty\u2010sex and age\u2010matched healthy donors were recruited as controls. IL\u201023 serum concentrations, measured by a quantitative enzyme immunoassay technique, were significantly higher in patients with resected CRC (26.02\u2009\u00b1\u200928.63\u2009pg\/ml versus 7.1\u2009\u00b1\u20096.4\u2009pg\/ml, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and after chemotherapy respect to controls (21.74\u2009\u00b1\u200923.82\u2009pg\/ml versus 7.17\u2009\u00b1\u20096.43\u2009pg\/ml, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). An increase was documented also before chemotherapy (26.02\u2009\u00b1\u200928.63\u2009pg\/ml versus 21.74\u2009\u00b1\u200923.82\u2009pg\/ml, <jats:italic>P<\/jats:italic>\u2009=\u20090.7) but not statistically significant. This work investigated, for the first time, the role of IL\u201023 in CRC resection and chemotherapy, showing no correlation with the severity of disease, tumor removal, and chemotherapeutic treatment. However, other works are needed to better clarify if IL\u201023 could be considered a key\u2010molecule in human CRC and a target for tumor treatment. J. Cell. Physiol. 226: 3032\u20133034, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcp.22653","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T14:31:08Z","timestamp":1296570668000},"page":"3032-3034","source":"Crossref","is-referenced-by-count":9,"title":["Role of interleukin\u201023 circulating levels increase in resected colorectal cancer before and after chemotherapy: Preliminary data and future perspectives"],"prefix":"10.1002","volume":"226","author":[{"given":"V.","family":"Adamo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Franchina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.L.","family":"Minciullo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Pace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Colonese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.R.R.","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Saitta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ferraro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Spatari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gangemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207577200"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5448"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20038"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-010-0849-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","unstructured":"KaigaT SatoM KanedaH IwakuraY TakayamaT TaharaH.2007.Systemic administration of IL\u201023 induces potent antitumor immunity primarily mediated through Th1\u2010type response in association with the endogenously expressed IL\u201012.","DOI":"10.4049\/jimmunol.178.12.7571"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04808"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.5784"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.2.600"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.09.014"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00700.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00070-4"},{"key":"e_1_2_5_13_1","first-page":"47","article-title":"Antitumor activity and immune enhancement of murine interleukin\u201023 expressed in murine colon carcinoma cells","volume":"3","author":"Shan BE","year":"2006","journal-title":"Cell Mol Immunol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-009-0091-9"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2005.02257.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-008-0588-8"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11160"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.22653","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.22653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T06:17:49Z","timestamp":1696918669000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.22653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,24]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1002\/jcp.22653"],"URL":"https:\/\/doi.org\/10.1002\/jcp.22653","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,24]]}}}