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MSCs are bone marrow (BM) multipotent cells supporting hematopoiesis with the potential to differentiate into multiple skeletal phenotypes. A recently identified new marker, CD146, allowing to prospectively isolate MSCs from BM, renders also possible their identification in different tissues. In order to elucidate the presence and functional role of MSCs in human bowel we analyzed normal adult colon sections and isolated MSCs from them. In colon (C) sections, resident MSCs form a net enveloping crypts in lamina propria, coinciding with structural myofibroblasts or interstitial stromal cells. Nine sub\u2010clonal CD146<jats:sup>+<\/jats:sup> MSC lines were derived and characterized from colon biopsies, in addition to MSC lines from five other human tissues. In spite of a phenotype qualitative identity between the BM\u2010 and C\u2010MSC populations, they were discriminated and categorized. Similarities between C\u2010MSC and BM\u2010MSCs are represented by: Osteogenic differentiation, hematopoietic supporting activity, immune\u2010modulation, and surface\u2010antigen qualitative expression. The differences between these populations are: C\u2010MSCs mean intensity expression is lower for CD13, CD29, and CD49c surface\u2010antigens, proliferative rate faster, life\u2010span shorter, chondrogenic differentiation rare, and adipogenic differentiation completely blocked. Briefly, BM\u2010MSCs, deserve the rank of progenitors, whereas C\u2010MSCs belong to the restricted precursor hierarchy. The presence and functional role of MSCs in human colon provide a rationale for BM\u2010MSC replacement therapy in CD, where resident bowel MSCs might be exhausted or diverted from their physiological functions. J. Cell. Physiol. 227: 3291\u20133300, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jcp.24027","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T15:04:19Z","timestamp":1323875059000},"page":"3291-3300","source":"Crossref","is-referenced-by-count":23,"title":["Identity and ranking of colonic mesenchymal stromal cells"],"prefix":"10.1002","volume":"227","author":[{"given":"Michele","family":"Signore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna 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