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A number of key energy metabolites including SAM, acetyl\u2010CoA, NAD<jats:sup>+<\/jats:sup>, and ATP serve as essential co\u2010factors for many, perhaps most, epigenetic enzymes that regulate DNA methylation, posttranslational histone modifications, and nucleosome position. The relative abundance of these energy metabolites allows a cell to sense its energetic state. And as co\u2010factors, energy metabolites act as rheostats to modulate the activity of epigenetic enzymes and upregulate\/downregulate transcription as appropriate to maintain homeostasis. J. Cell. Physiol. 227: 3169\u20133177, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jcp.24054","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T13:41:48Z","timestamp":1326980508000},"page":"3169-3177","source":"Crossref","is-referenced-by-count":282,"title":["Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression"],"prefix":"10.1002","volume":"227","author":[{"given":"Dallas R.","family":"Donohoe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott 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