{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:50:29Z","timestamp":1790387429036,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T00:00:00Z","timestamp":1353628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>PATZ1<\/jats:italic>is an emerging cancer\u2010related gene coding for a POZ\/AT\u2010hook\/kruppel Zinc finger transcription factor, which is lost or misexpressed in human neoplasias. Here, we investigated its role in development exploring wild\u2010type and Patz1\u2010knockout mice during embryogenesis. We report that the<jats:italic>Patz1<\/jats:italic>gene is ubiquitously expressed at early stages of development and becomes more restricted at later stages, with high levels of expression in actively proliferating neuroblasts belonging to the ventricular zones of the central nervous system (CNS). The analysis of embryos in which<jats:italic>Patz1<\/jats:italic>was disrupted revealed the presence of severe defects in the CNS and in the cardiac outflow tract, which eventually lead to a pre\u2010mature in utero death during late gestation or soon after birth. Moreover, the Patz1\u2010null mice showed a general growth retardation, which was consistent with the slower growth rate and the increased susceptibility to senescence of Patz1<jats:sup>\u2212\/\u2212<\/jats:sup>mouse embryonic fibroblasts (MEFs) compared to wild\u2010type controls. Therefore, these results indicate a critical role of PATZ1 in the control of cell growth and embryonic development. J. Cell. Physiol. 228: 646\u2013653, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jcp.24174","type":"journal-article","created":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T12:41:06Z","timestamp":1344516066000},"page":"646-653","source":"Crossref","is-referenced-by-count":37,"title":["Embryonic defects and growth alteration in mice with homozygous disruption of the<i>Patz1<\/i>gene"],"prefix":"10.1002","volume":"228","author":[{"given":"Teresa","family":"Valentino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Palmieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Vitiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Simeone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Arra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Chieffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Chiariotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Fusco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Fedele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1311"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.embor806"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1366"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-59"},{"key":"e_1_2_6_6_1","first-page":"2439","article-title":"High level expression of the HMGI (Y) gene during embryonic development","volume":"13","author":"Chiappetta G","year":"1996","journal-title":"Oncogene"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.142"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/elm002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1367"},{"key":"e_1_2_6_10_1","first-page":"5633","article-title":"Cancer as a complex developmental disorder\u2014Nineteenth Cornelius P. Rhoads Memorial Award Lecture","volume":"58","author":"Dean M","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2003.08.012"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2008.00369.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2846"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.11.7894"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.04.024"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2323"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2006.12.004"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420440211"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.10.020"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.5.1733-1746.2000"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.20.11032"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-8-389"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203762"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.7.2485-2495.2001"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110392200"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-011-0174-5"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109491200"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.346270"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02760486"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1860"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/85784"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81902-9"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970516)70:2<155::AID-AJMG10>3.0.CO;2-I"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/35102174"},{"key":"e_1_2_6_35_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-88418-4","volume-title":"The house mouse (atlas of embryonic development), ed","author":"Theiler K","year":"1989"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7270.2008.00405.x"},{"key":"e_1_2_6_37_1","first-page":"865","article-title":"siRNA down\u2010regulation of the PATZ1 gene in human glioma cells increases their sensitivity to apoptotic stimuli","volume":"6","author":"Tritz R","year":"2008","journal-title":"Cancer Ther"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1627-07.2007"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.12.026"},{"key":"e_1_2_6_40_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S1016-8478(23)17496-6","article-title":"Reduction of UV\u2010induced cell death in the human senescent fibroblasts","volume":"10","author":"Yeo EJ","year":"2000","journal-title":"Mol Cell"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06562"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.24174","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.24174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T08:41:10Z","timestamp":1714293670000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.24174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,23]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1002\/jcp.24174"],"URL":"https:\/\/doi.org\/10.1002\/jcp.24174","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,23]]}}}