{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:36:23Z","timestamp":1783064183026,"version":"3.54.6"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T00:00:00Z","timestamp":1400803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>Proteasome modulator 9 (<jats:italic>PSMD9<\/jats:italic>) gene single nucleotide polymorphism (SNP) rs1043307\/rs2514259 (<jats:italic>E197G<\/jats:italic>) is associated with significant clinical response to the anti\u2010depressant desipramine. <jats:italic>PSMD9<\/jats:italic> SNP rs74421874 [<jats:italic>intervening sequence<\/jats:italic> (<jats:italic>IVS<\/jats:italic>) 3\u2009+\u2009<jats:italic>nt<\/jats:italic>460 <jats:italic>G&gt;A<\/jats:italic>], rs3825172 (<jats:italic>IVS3<\/jats:italic>\u2009<jats:italic>+\u2009nt437 C&gt;T<\/jats:italic>) and rs1043307\/rs2514259 (<jats:italic>E197G A&gt;G<\/jats:italic>) are all linked to type 2 diabetes (T2D), maturity\u2010onset\u2010diabetes\u2010of the young 3 (MODY3), obesity and waist circumference, hypertension, hypercholesterolemia, T2D\u2010macrovascular and T2D\u2010microvascular disease, T2D\u2010neuropathy, T2D\u2010carpal tunnel syndrome, T2D\u2010nephropathy, T2D\u2010retinopathy, non\u2010diabetic retinopathy and depression. <jats:italic>PSMD9<\/jats:italic> rs149556654 rare SNP (<jats:italic>N166S A&gt;G<\/jats:italic>) and the variant <jats:italic>S143G A&gt;G<\/jats:italic> also contribute to T2D. <jats:italic>PSMD9<\/jats:italic> is located in the chromosome 12q24 locus, which per se is in linkage with depression, bipolar disorder and anxiety. In the present study, we wanted to determine whether <jats:italic>PSMD9<\/jats:italic> is linked to general anxiety disorder in Italian T2D families. Two\u2010hundred Italian T2D families were phenotyped for generalized anxiety disorder, using the diagnostic criteria of DSM\u2010IV. When the diagnosis was unavailable or unclear, the trait was reported as unknown. The 200 Italians families were tested for the <jats:italic>PSMD9<\/jats:italic> T2D risk SNPs rs74421874 (<jats:italic>IVS3<\/jats:italic>\u2009<jats:italic>+\u2009nt460 G&gt;A<\/jats:italic>), rs3825172 (<jats:italic>IVS3\u2009+nt437 T&gt;C<\/jats:italic>) and for the T2D risk and anti\u2010depressant response SNP rs1043307\/rs2514259 (<jats:italic>E197G A&gt;G<\/jats:italic>) for evidence of linkage with generalized anxiety disorder. Non\u2010parametric linkage analysis was executed via Merlin software. One\u2010thousand simulation tests were performed to exclude results due to random chance. In our study, the <jats:italic>PSMD9<\/jats:italic> gene SNPs rs74421874, rs3825172, and rs1043307\/rs2514259 result in linkage to generalized anxiety disorder. This is the first report describing <jats:italic>PSMD9<\/jats:italic> gene SNPs in linkage to generalized anxiety disorder in T2D families. J. Cell. Physiol. 229: 1157\u20131159, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.24581","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T09:50:00Z","timestamp":1392630600000},"page":"1157-1159","source":"Crossref","is-referenced-by-count":18,"title":["Proteasome Modulator 9 Gene SNPs, Responsible for Anti\u2010Depressant Response, Are in Linkage With Generalized Anxiety Disorder"],"prefix":"10.1002","volume":"229","author":[{"given":"Claudia","family":"Gragnoli","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Genetics of Complex and Monogenic Disorders Department of Medicine Penn State University and M. S. Hershey Medical Center Hershey Pennsylvania"},{"name":"Molecular Biology Laboratory Bios Biotech Multi\u2010Diagnostic Health Center Rome Italy"},{"name":"Center for Biotechnology and Department of Biology Temple University's College of Science &amp; Technology Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng786"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M800194-JLR200"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30524"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30841"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1663"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.307"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(200002)15:2<173::AID-HUMU6>3.0.CO;2-W"},{"key":"e_1_2_6_9_1","first-page":"97","article-title":"Kir6.2 (KCNJ11) E23K variant in Type 2 diabetes in Italians","volume":"3","author":"Gragnoli C","year":"2007","journal-title":"Obes Metab"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21553"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21954"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-10-38"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.07.040"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-10-32"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","unstructured":"GragnoliC.2011d. 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