{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:18:32Z","timestamp":1740104312162,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2012CB517803"],"award-info":[{"award-number":["2012CB517803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81173049; 81121003; 81373406"],"award-info":[{"award-number":["81173049; 81121003; 81373406"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:label\/><jats:p>Our previous work showed that the expression of bone morphogenetic protein\u20104 (BMP4) was up\u2010regulated in pathological cardiac hypertrophy models and BMP4 induced cardiomyocyte hypertrophy and apoptosis. Bone morphogenetic protein\u20102 (BMP2) and BMP4 share greater than 80% amino acid homology and there exists an interaction between BMP2 and BMP4, so the aim of the present study was to elucidate the changes of BMP2 in the cardiac hypertrophy models and the effects of BMP2 on BMP4\u2010induced cardiomyocyte hypertrophy and apoptosis. The in vivo cardiac hypertrophy models were induced by pressure\u2010overload and swimming exercise in mice. BMP2 mRNA and protein expressions increased in pressure\u2010overload and swimming\u2010exercise induced cardiac hypertrophy. BMP2 itself did not elicit cardiomyocyte hypertrophy and apoptosis, but antagonized BMP4\u2010induced cardiomyocyte hypertrophy and apoptosis. BMP2 stimulated Akt in cardiomyocytes and Akt inhibitor prevented the antagonism of BMP2 on BMP4\u2010induced cardiomyocyte apoptosis. Furthermore, BMP2 inhibited BMP4\u2010induced JNK activation in cardiomyocytes. In conclusion, BMP2 antagonizes BMP4\u2010induced cardiomyocyte hypertrophy and apoptosis. The anti\u2010apoptotic effects of BMP2 on BMP4\u2010induced cardiomyocyte apoptosis might be through activating Akt and inhibiting JNK activation. J. Cell. Physiol. 229: 1503\u20131510, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.24592","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T17:57:41Z","timestamp":1393264661000},"page":"1503-1510","source":"Crossref","is-referenced-by-count":20,"title":["Bone Morphogenetic Protein\u20102 Antagonizes Bone Morphogenetic Protein\u20104 Induced Cardiomyocyte Hypertrophy and Apoptosis"],"prefix":"10.1002","volume":"229","author":[{"given":"Jing","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pharmacology (The State\u2010Province Key Laboratories of Biomedicine\u2010Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education) Harbin Medical University Harbin 150086 P.R. 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