{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:17:01Z","timestamp":1791314221092,"version":"4.3.1"},"reference-count":62,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T00:00:00Z","timestamp":1406592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T00:00:00Z","timestamp":1406592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Instituto de Salud Carlos-III (Spanish Competitiveness Ministry)","award":["CIBERES"],"award-info":[{"award-number":["CIBERES"]}]},{"name":"Instituto de Salud Carlos-III (Spanish Competitiveness Ministry)","award":["FIS 11\/02029"],"award-info":[{"award-number":["FIS 11\/02029"]}]},{"name":"Instituto de Salud Carlos-III (Spanish Competitiveness Ministry)","award":["FIS 12\/02534"],"award-info":[{"award-number":["FIS 12\/02534"]}]},{"name":"Generalitat de Catalunya (Catalan Government)","award":["2009-SGR-393"],"award-info":[{"award-number":["2009-SGR-393"]}]},{"DOI":"10.13039\/501100007509","name":"Spanish Respiratory Society (SEPAR)","doi-asserted-by":"crossref","award":["SEPAR 2010"],"award-info":[{"award-number":["SEPAR 2010"]}],"id":[{"id":"10.13039\/501100007509","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Catalan Foundation of Pulmonology","award":["FUCAP 2011"],"award-info":[{"award-number":["FUCAP 2011"]}]},{"name":"Catalan Foundation of Pulmonology","award":["FUCAP 2012"],"award-info":[{"award-number":["FUCAP 2012"]}]},{"name":"Marato de TV3","award":["MTV3-07-1010"],"award-info":[{"award-number":["MTV3-07-1010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Cachexia is a relevant comorbid condition of chronic diseases including cancer. Inflammation, oxidative stress, autophagy, ubiquitin\u2013proteasome system, nuclear factor (NF)\u2010\u03baB, and mitogen\u2010activated protein kinases (MAPK) are involved in the pathophysiology of cancer cachexia. Currently available treatment is limited and data demonstrating effectiveness in in vivo models are lacking. Our objectives were to explore in respiratory and limb muscles of lung cancer (LC) cachectic mice whether proteasome, NF\u2010\u03baB, and MAPK inhibitors improve muscle mass and function loss through several molecular mechanisms. Body and muscle weights, limb muscle force, protein degradation and the ubiquitin\u2013proteasome system, signaling pathways, oxidative stress and inflammation, autophagy, contractile and functional proteins, myostatin and myogenin, and muscle structure were evaluated in the diaphragm and gastrocnemius of LC (LP07 adenocarcinoma) bearing cachectic mice (BALB\/c), with and without concomitant treatment with NF\u2010\u03baB (sulfasalazine), MAPK (U0126), and proteasome (bortezomib) inhibitors. Compared to control animals, in both respiratory and limb muscles of LC cachectic mice: muscle proteolysis, ubiquitinated proteins, autophagy, myostatin, protein oxidation, FoxO\u20101, NF\u2010\u03baB and MAPK signaling pathways, and muscle abnormalities were increased, while myosin, creatine kinase, myogenin, and slow\u2010 and fast\u2010twitch muscle fiber size were decreased. Pharmacological inhibition of NF\u2010\u03baB and MAPK, but not the proteasome system, induced in cancer cachectic animals, a substantial restoration of muscle mass and force through a decrease in muscle protein oxidation and catabolism, myostatin, and autophagy, together with a greater content of myogenin, and contractile and functional proteins. Attenuation of MAPK and NF\u2010\u03baB signaling pathway effects on muscles is beneficial in cancer\u2010induced cachexia. J. Cell. Physiol. 229: 1660\u20131672, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.24611","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T04:17:18Z","timestamp":1394425038000},"page":"1660-1672","source":"Crossref","is-referenced-by-count":79,"title":["Pharmacological Strategies in Lung Cancer\u2010Induced Cachexia: Effects on Muscle Proteolysis, Autophagy, Structure, and Weakness"],"prefix":"10.1002","volume":"229","author":[{"given":"Alba","family":"Chacon\u2010Cabrera","sequence":"first","affiliation":[{"name":"Pulmonology\u2010Lung Cancer Research Group, IMIM\u2010Hospital del Mar, Parc de Salut Mar, Health and Experimental Sciences Department (CEXS) Universitat Pompeu Fabra (UPF) Parc de Recerca Biom\u00e8dica de Barcelona (PRBB) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Respiratorias (CIBERES) Instituto de Salud Carlos III (ISCIII) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Fermoselle","sequence":"additional","affiliation":[{"name":"Pulmonology\u2010Lung Cancer Research Group, IMIM\u2010Hospital del Mar, Parc de Salut Mar, Health and Experimental Sciences Department (CEXS) Universitat Pompeu Fabra (UPF) Parc de Recerca Biom\u00e8dica de Barcelona (PRBB) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Respiratorias (CIBERES) Instituto de Salud Carlos III (ISCIII) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro J.","family":"Urtreger","sequence":"additional","affiliation":[{"name":"Research Area Institute of Oncology \u2018Angel H. Roffo\u2019 University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Mateu\u2010Jimenez","sequence":"additional","affiliation":[{"name":"Pulmonology\u2010Lung Cancer Research Group, IMIM\u2010Hospital del Mar, Parc de Salut Mar, Health and Experimental Sciences Department (CEXS) Universitat Pompeu Fabra (UPF) Parc de Recerca Biom\u00e8dica de Barcelona (PRBB) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Respiratorias (CIBERES) Instituto de Salud Carlos III (ISCIII) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam J.","family":"Diament","sequence":"additional","affiliation":[{"name":"Research Area Institute of Oncology \u2018Angel H. Roffo\u2019 University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa D. 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