{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T13:33:34Z","timestamp":1777815214825,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["WE2458\/7-2"],"award-info":[{"award-number":["WE2458\/7-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>In female mammals, granulosa cells of the ovarian follicle differentiate into the corpus luteum after ovulation of the pregnable oocyte into the fallopian tube. During these differentiation processes several morphological alterations have to occur and the molecular basis is not fully understood. As an endpoint estradiol production from granulosa cells has to switch off in favor for progesterone production from the proceeding corpus luteum to sustain the developing embryo. Previously, we demonstrated that the multiligand receptor LOX\u20101 plays a critical role in steroid hormone synthesis of granulosa cells via intracellular calcium release from endoplasmic (ER)\u2010dependent and ER\u2010independent calcium pools. In the present study, we show that inhibition of LOX\u20101 leads to a rearrangement of ceramide from the basal membrane toward the Golgi apparatus. This activity is accomplished by a calcium\u2010dependent phosphorylation of aromatase, the key step in estradiol production. Phosphorylated aromatase increased estradiol production in a dose\u2010dependent manner. Our data indicate that the ceramide cascade is essential for proper granulosa cell function and ceramide redistribution serves as a first step in order to proceed with the prosperous differentiation into a corpus luteum. J. Cell. Physiol. 229: 1946\u20131951, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.24644","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T09:42:52Z","timestamp":1396950172000},"page":"1946-1951","source":"Crossref","is-referenced-by-count":6,"title":["Inactivation of the LOX\u20101 Pathway Promotes the Golgi Apparatus during Cell Differentiation of Mural Granulosa Cells"],"prefix":"10.1002","volume":"229","author":[{"given":"J.M.","family":"Weitzel","sequence":"first","affiliation":[{"name":"Institute of Reproductive Biology Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vernunft","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Biology Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf 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