{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:06:16Z","timestamp":1780452376337,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"March of Dimes Basil O'Connor award (#5-FY14-33) and a Vermont Cancer Center and Lake Champlain Cancer Research Organization Pilot Grant"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH)","doi-asserted-by":"crossref","award":["P01 CA082834"],"award-info":[{"award-number":["P01 CA082834"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH)","doi-asserted-by":"crossref","award":["R01 CA139322"],"award-info":[{"award-number":["R01 CA139322"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH)","doi-asserted-by":"crossref","award":["NIH 5 R01 HL079582-11"],"award-info":[{"award-number":["NIH 5 R01 HL079582-11"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH)","doi-asserted-by":"crossref","award":["R24 DK099808-01"],"award-info":[{"award-number":["R24 DK099808-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Chromosome segregation and spindle microtubule dynamics are strictly coordinated during cell division in order to preserve genomic integrity. Alterations in the genome that affect microtubule stability and spindle assembly during mitosis may contribute to genomic instability and cancer predisposition, but directly testing this potential link poses a significant challenge. Germ\u2010line mutations in tumor suppressor genes that predispose patients to cancer and alter spindle microtubule dynamics offer unique opportunities to investigate the relationship between spindle dysfunction and carcinogenesis. Mutations in two such tumor suppressors, adenomatous polyposis coli (APC) and Shwachman\u2013Bodian\u2013Diamond syndrome (SBDS), affect multifunctional proteins that have been well characterized for their roles in Wnt signaling and interphase ribosome assembly, respectively. Less understood, however, is how their shared involvement in stabilizing the microtubules that comprise the mitotic spindle contributes to cancer predisposition. Here, we briefly discuss the potential for mutations in APC and SBDS as informative tools for studying the impact of mitotic spindle dysfunction on cellular transformation. J. Cell. Physiol. 229: 1881\u20131883, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.24691","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T11:55:09Z","timestamp":1402055709000},"page":"1881-1883","source":"Crossref","is-referenced-by-count":18,"title":["Spindle Microtubule Dysfunction and Cancer Predisposition"],"prefix":"10.1002","volume":"229","author":[{"given":"Jason","family":"Stumpff","sequence":"first","affiliation":[{"name":"Vermont Cancer Center and Department of Molecular Physiology and Biophysics University of Vermont College of Medicine Burlington Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi N.","family":"Ghule","sequence":"additional","affiliation":[{"name":"Vermont Cancer Center and Department of Biochemistry University of Vermont College of Medicine Burlington Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Shimamura","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington"},{"name":"Seattle Children's Hospital and University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet L.","family":"Stein","sequence":"additional","affiliation":[{"name":"Vermont Cancer Center and Department of Biochemistry University of Vermont College of Medicine Burlington Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Greenblatt","sequence":"additional","affiliation":[{"name":"Vermont Cancer Center and Department of Medicine University of Vermont College of Medicine Burlington Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,27]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"163","article-title":"The differential diagnosis and surveillance of hereditary gastrointestinal polyposis syndromes","volume":"107","author":"Aretz S","year":"2010","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33764"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59954"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2011.11.012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.09.055"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1809"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1062"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200703186"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20478"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1897-4287-3-3-95"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08136"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200307070"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e05-03-0259"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(81)90021-0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.01.054"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/35070123"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1651562"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.18.032002.132412"},{"key":"e_1_2_7_20_1","first-page":"3676","article-title":"The APC gene product associates with microtubules in vivo and promotes their assembly in vitro","volume":"54","author":"Munemitsu S","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.100479"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-419X(97)00008-5"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2006.04.006"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006564"},{"key":"e_1_2_7_25_1","first-page":"3672","article-title":"Wild\u2010type but not mutant APC associates with the microtubule cytoskeleton","volume":"54","author":"Smith KJ","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01556"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.24691","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.24691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T13:09:15Z","timestamp":1696597755000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.24691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,27]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1002\/jcp.24691"],"URL":"https:\/\/doi.org\/10.1002\/jcp.24691","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,27]]}}}