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Cysteinyl leukotrienes (cys\u2010LTs) are potent inflammatory mediators that signal through CysLT<jats:sub>1<\/jats:sub>R and CysLT<jats:sub>2<\/jats:sub>R located on the MC surface, and they enhance MC inflammatory responses. However, it is not known if SCF and cys\u2010LTs cross\u2010talk and influence MC hyperplasia and activation in inflammation. Here, we report the concerted effort of the growth factor SCF and the inflammatory mediator LTD<jats:sub>4<\/jats:sub> in MC activation. Stimulation of MCs by LTD<jats:sub>4<\/jats:sub> in the presence of SCF enhances c\u2010Kit\u2010mediated proliferative responses. Similarly, SCF synergistically enhances LTD<jats:sub>4<\/jats:sub>\u2010induced calcium, c\u2010fos expression and phosphorylation, as well as MIP1\u03b2 generation in MCs. These findings suggest that integration of SCF and LTD<jats:sub>4<\/jats:sub> signals may contribute to MC hyperplasia and hyper\u2010reactivity during airway hyper\u2010response and inflammation. J. Cell. Physiol. 230: 595\u2013602, 2015. \u00a9 2014 Wiley Periodicals, Inc., A Wiley Company<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.24777","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T10:55:14Z","timestamp":1409136914000},"page":"595-602","source":"Crossref","is-referenced-by-count":22,"title":["Modulation of Mast Cell Proliferative and Inflammatory Responses by Leukotriene D<sub>4<\/sub> and Stem Cell Factor Signaling Interactions"],"prefix":"10.1002","volume":"230","author":[{"given":"Nosayba","family":"Al\u2010Azzam","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Akron Akron Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay","family":"Kondeti","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Akron Akron 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