{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:50Z","timestamp":1786978010862,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T00:00:00Z","timestamp":1422403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"crossref","award":["NSC 101-2320-B-037-043-MY3"],"award-info":[{"award-number":["NSC 101-2320-B-037-043-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Science and Technology","award":["MOST 103-2320-B-037-006-MY3"],"award-info":[{"award-number":["MOST 103-2320-B-037-006-MY3"]}]},{"name":"Ministry of Science and Technology","award":["MOST 103-2314-B-037-052"],"award-info":[{"award-number":["MOST 103-2314-B-037-052"]}]},{"name":"Kaohsiung Medical University Hospital","award":["KMUH101-1M08"],"award-info":[{"award-number":["KMUH101-1M08"]}]},{"name":"Kaohsiung Medical University Hospital","award":["KMUH102-2M06"],"award-info":[{"award-number":["KMUH102-2M06"]}]},{"name":"Chi-Mei Medical Center and Kaohsiung Medical University Research Foundation","award":["HSU 103CM-KMU-03"],"award-info":[{"award-number":["HSU 103CM-KMU-03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Chronic inflammatory airway diseases like asthma and chronic obstructive pulmonary disease are major health problems globally. Airway epithelial cells play important role in airway remodeling, which is a critical process in the pathogenesis of diseases. This study aimed to demonstrate that LIGHT, an inflammatory factor secreted by T cells after allergen exposure, is responsible for promoting airway remodeling. LIGHT increased primary human bronchial epithelial cells (HBECs) undergoing epithelial\u2010mesenchymal transition (EMT) and expressing MMP\u20109. The induction of EMT was associated with increased NF\u2010\u03baB activation and p300\/NF\u2010\u03baB association. The interaction of NF\u2010\u03baB with p300 facilitated NF\u2010\u03baB acetylation, which in turn, was bound to the promoter of ZEB1, resulting in E\u2010cadherin downregulation. LIGHT also stimulated HBECs to produce numerous cytokines\/chemokines that could worsen airway inflammation. Furthermore, LIGHT enhanced HBECs to secrete activin A, which increased bronchial smooth muscle cell (BSMC) migration. In contrast, depletion of activin A decreased such migration. The findings suggest a new molecular determinant of LIGHT\u2010mediated pathogenic changes in HBECs and that the LIGHT\u2010related vicious cycle involving HBECs and BSMCs may be a potential target for the treatment of chronic inflammation airway diseases with airway remodeling. J. Cell. 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