{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:43:16Z","timestamp":1773308596797,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T00:00:00Z","timestamp":1424822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>The aim of this study is to establish a recapitulation system of human endochondral ossification as a paradigm of developmental engineering. Chondrocytes were isolated from the epiphyseal cartilage of the supernumerary digits of infants with polydactyly. In vivo studies showed that implanted chondrocytes exhibited cartilaginous regeneration over a short period of time and subsequent endochondral ossification with a marrow cavity. Tracing studies revealed that cells of donor origin at the periphery of the cartilage migrated into the center of the cartilage and transformed into osteoblasts, adipocytes, and endothelial cells. Bone marrow was formed through anastomosis with the recipient endothelial system at 13 weeks, and from the migration of recipient hematopoietic cells at 50 weeks. This study provides a human endochondral ossification model system with transdifferentiation of the donor cells at the periphery of the cartilage. J. Cell. Physiol. 230: 1376\u20131388, 2015. \u00a9 2015 Wiley Periodicals, Inc., A Wiley Company<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.24882","type":"journal-article","created":{"date-parts":[[2015,1,3]],"date-time":"2015-01-03T10:55:12Z","timestamp":1420282512000},"page":"1376-1388","source":"Crossref","is-referenced-by-count":16,"title":["Endochondral Ossification Model System: Designed Cell Fate of Human Epiphyseal Chondrocytes During Long\u2010Term Implantation"],"prefix":"10.1002","volume":"230","author":[{"given":"Michiyo","family":"Nasu","sequence":"first","affiliation":[{"name":"Department of Reproductive Biology National Research Institute for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery National Research Institute for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Umezawa","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology National Research Institute for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011700"},{"key":"e_1_2_6_3_1","first-page":"707","article-title":"Developmental control of chondrogenesis and osteogenesis","volume":"44","author":"Cancedda R","year":"2000","journal-title":"Int J Dev Biol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.02.026"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(03)00036-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.117.2.427"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00912"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650090814"},{"key":"e_1_2_6_9_1","first-page":"165","volume-title":"Connecitve tissue. Color textbook of histology","author":"Gartner LP","year":"2006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.51.32419"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-010-0199-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(03)00130-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E11-10-0869"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197711000-00042"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.06.009"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2005.05.027"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.12.5183-5195.2005"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80520-1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370912"},{"key":"e_1_2_6_20_1","first-page":"173","volume-title":"Cartilage: bone and bone development. Histology: A text and atlas","author":"Rhodin JAG","year":"1974"},{"key":"e_1_2_6_21_1","first-page":"76","volume-title":"Histology for pathologists","author":"Rosenberg AE","year":"2007"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2013.09.008"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807859200"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21125"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.94B4.27117"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.24882","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.24882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T22:44:25Z","timestamp":1696373065000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.24882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,25]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1002\/jcp.24882"],"URL":"https:\/\/doi.org\/10.1002\/jcp.24882","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,25]]}}}