{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:38:34Z","timestamp":1777610314017,"version":"3.51.4"},"reference-count":91,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":158,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Cell. Physiol."],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1002\/jcp.24909","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T14:10:44Z","timestamp":1419343844000},"page":"1614-1629","source":"Crossref","is-referenced-by-count":29,"title":["Human olfactory bulb neural stem cells mitigate movement disorders in a rat model of Parkinson's disease"],"prefix":"10.1002","volume":"230","author":[{"given":"Hany E.S.","family":"Marei","sequence":"first","affiliation":[{"name":"Department of Cytology and Histology; Faculty of Veterinary Medicine; Mansoura University; Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samah","family":"Lashen","sequence":"additional","affiliation":[{"name":"Department of Cytology and Histology; Faculty of Veterinary Medicine; Mansoura University; Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany","family":"Farag","sequence":"additional","affiliation":[{"name":"Department of Cytology and Histology; Faculty of Veterinary Medicine; Mansoura University; Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa","family":"Althani","sequence":"additional","affiliation":[{"name":"College of Arts & Sciences; Health Sciences Department; Qatar University; Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahla","family":"Afifi","sequence":"additional","affiliation":[{"name":"Department of Anatomy; Faculty of Medicine; Ain Shams University; Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abd-Elmaksoud","family":"A","sequence":"additional","affiliation":[{"name":"Department of Cytology and Histology; Faculty of Veterinary Medicine; Mansoura University; Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaymaa","family":"Rezk","sequence":"additional","affiliation":[{"name":"Department of Cytology and Histology; Faculty of Veterinary Medicine; Mansoura University; Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Pallini","sequence":"additional","affiliation":[{"name":"Institute of Neurosurgery; University Cattolica del Sacro Cuore; Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Casalbore","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Neurobiology; National Research Council of Italy; Rome-Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Cenciarelli","sequence":"additional","affiliation":[{"name":"Institute of Translational Pharmacology; National Research Council of Italy; Rome-Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"10.1002\/jcp.24909-BIB0001|jcp24909-cit-0001","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0301-0082(99)00032-5","article-title":"Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases","volume":"60","author":"Alexi","year":"2000","journal-title":"Prog Neurobiol"},{"key":"10.1002\/jcp.24909-BIB0002|jcp24909-cit-0002","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0006-8993(89)90857-3","article-title":"Microglial response to 6- hydroxydopamine induced substantia nigra lesions","volume":"489","author":"Akiyama","year":"1989","journal-title":"Brain Res"},{"key":"10.1002\/jcp.24909-BIB0003|jcp24909-cit-0003","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s00415-008-5004-3","article-title":"Epidemiology of Parkinson's disease","volume":"255","author":"Alves","year":"2008","journal-title":"J Neurol"},{"key":"10.1002\/jcp.24909-BIB0004|jcp24909-cit-0004","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0959-8049(95)00049-O","article-title":"Effects of stem cell factor and other bone marrow-derived growth factors on the expression of adhesion molecules and proliferation of human neuroblastoma cells","volume":"31A","author":"Beck","year":"1995","journal-title":"Eur J Cancer"},{"key":"10.1002\/jcp.24909-BIB0005|jcp24909-cit-0005","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1002\/mds.21065","article-title":"The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered","volume":"21","author":"Braak","year":"2006","journal-title":"Mov Disord"},{"key":"10.1002\/jcp.24909-BIB0006|jcp24909-cit-0006","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3727\/000000005783983098","article-title":"Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine-hydroxylase positive cells found in the striatum: A return to control measures","volume":"14","author":"Bjugstad","year":"2005","journal-title":"Cell Transplant"},{"key":"10.1002\/jcp.24909-BIB0007|jcp24909-cit-0007","doi-asserted-by":"crossref","first-page":"14809","DOI":"10.1073\/pnas.94.26.14809","article-title":"In vitro generated neural precursors participate in mammalian brain development","volume":"94","author":"Brustle","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/jcp.24909-BIB0008|jcp24909-cit-0008","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.1073\/pnas.1132092100","article-title":"Neural stem cells and cholinergic neurons: Regulation by immunolesion and treatment with mitogens, retinoic acid, and nerve growth factor","volume":"100","author":"Calza","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/jcp.24909-BIB0009|jcp24909-cit-0009","doi-asserted-by":"crossref","first-page":"e373","DOI":"10.1371\/journal.pone.0000373","article-title":"Neurosphere-derived cells exert a neuroprotective action by changing the ischemic microenvironment","volume":"2","author":"Capone","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1002\/jcp.24909-BIB0010|jcp24909-cit-0010","first-page":"170","article-title":"Histotechnology: A Self-Instructional","author":"Carson","year":"1990","journal-title":"Text"},{"key":"10.1002\/jcp.24909-BIB0011|jcp24909-cit-0011","doi-asserted-by":"crossref","first-page":"e4434","DOI":"10.1371\/journal.pone.0004434","article-title":"Tumorigenic Potential of Olfactory Bulb-Derived Human Adult Neural Stem Cells Associates with Activation of TERT and NOTCH1","volume":"4","author":"Casalbore","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1002\/jcp.24909-BIB0012|jcp24909-cit-0012","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1179\/016164106X115161","article-title":"In vitro analysis of mouse neural stem cells genetically modified to stably express human NGF by a novel multigenic viral expression system","volume":"28","author":"Cenciarelli","year":"2006","journal-title":"Neurol Res"},{"key":"10.1002\/jcp.24909-BIB0013|jcp24909-cit-0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1389450043490596","article-title":"Neurokinin peptides and neurokinin receptors as potential therapeutic intervention targets of basal ganglia in the prevention and treatment of Parkinson's disease","volume":"5","author":"Chen","year":"2004","journal-title":"Current Drug Targets"},{"key":"10.1002\/jcp.24909-BIB0014|jcp24909-cit-0014","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.expneurol.2007.01.014","article-title":"Midbrain expression of Delta-like 1 homologue is regulated by GDNF and is associated with dopaminergic differentiation","volume":"204","author":"Christophersen","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1002\/jcp.24909-BIB0015|jcp24909-cit-0015","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1046\/j.1460-9568.2002.01938.x","article-title":"Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging","volume":"15","author":"Cicchetti","year":"2002","journal-title":"Eur J Neurosci"},{"key":"10.1002\/jcp.24909-BIB0016|jcp24909-cit-0016","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1111\/j.1471-4159.2004.02415.x","article-title":"Effects of 6-hydroxydopamine on primary cultures of substantia nigra: specific damage to dopamine neurons and the impact of glial cell line-derived neurotrophic factor","volume":"89","author":"Ding","year":"2004","journal-title":"J Neurochem"},{"key":"10.1002\/jcp.24909-BIB0017|jcp24909-cit-0017","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0014-4886(03)00212-7","article-title":"Survival and differentiation of adult rat-derived neural progenitor cells transplanted to the striatum of hemiparkinsonian rats","volume":"183","author":"Dziewczapolski","year":"2003","journal-title":"Exp Neurol"},{"key":"10.1002\/jcp.24909-BIB0018|jcp24909-cit-0018","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s10616-011-9379-0","article-title":"Optimal time for passaging neurospheres based on primary neural stem cell cultures","volume":"63","author":"Fangling","year":"2011","journal-title":"Cytotechnology"},{"key":"10.1002\/jcp.24909-BIB0019|jcp24909-cit-0019","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1073\/pnas.062039699","article-title":"Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinson's disease?","volume":"99","author":"Freed","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/jcp.24909-BIB0020|jcp24909-cit-0020","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.conb.2005.12.004","article-title":"Sculpting the nervous system: glial control of neuronal development","volume":"16","author":"Freeman","year":"2006","journal-title":"Curr Opin Neurobiol"},{"key":"10.1002\/jcp.24909-BIB0021|jcp24909-cit-0021","doi-asserted-by":"crossref","first-page":"10177","DOI":"10.1073\/pnas.0401229101","article-title":"No evidence for new dopaminergic neurons in the adult mammalian substantia nigra","volume":"101","author":"Frielingsdorf","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/jcp.24909-BIB0022|jcp24909-cit-0022","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/0192623310389621","article-title":"Histology of the central nervous system","volume":"39","author":"Garman","year":"2011","journal-title":"Toxicol Pathol"},{"key":"10.1002\/jcp.24909-BIB0023|jcp24909-cit-0023","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1002\/ana.410440718","article-title":"Neuroprotective and neurorestorative properties of GDNF","volume":"44","author":"Gash","year":"1998","journal-title":"Ann Neurol"},{"key":"10.1002\/jcp.24909-BIB0024|jcp24909-cit-0024","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/BF01291788","article-title":"Animal models of Parkinson's disease: An empirical comparison with the phenomenology of the disease in man","volume":"103","author":"Gerlach","year":"1996","journal-title":"J Neural Transm."},{"key":"10.1002\/jcp.24909-BIB0025|jcp24909-cit-0025","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nbt1119","article-title":"Stem and progenitor cell-based therapy of the human central nervous system","volume":"23","author":"Goldman","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1002\/jcp.24909-BIB0026|jcp24909-cit-0026","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/10715769900301611","article-title":"Time course of dopaminergic cell death and changes in iron, ferritin and transferring levels in the rat substantia nigra after 6-hydroxydopamine (6-OHDA) lesioning","volume":"31","author":"He","year":"1999","journal-title":"Free Radical Res"},{"key":"10.1002\/jcp.24909-BIB0027|jcp24909-cit-0027","first-page":"579","volume-title":"The rat nervous system","author":"Heimer","year":"1995"},{"key":"10.1002\/jcp.24909-BIB0028|jcp24909-cit-0028","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1517\/14712598.6.7.653","article-title":"Epigenetic conversion of human adult bone mesodermal stromal cells into neuroectodermal cell types for replacement therapy of neurodegenerative disorders","volume":"6","author":"Hermann","year":"2006","journal-title":"Expert Opin Biol Ther"},{"key":"10.1002\/jcp.24909-BIB0029|jcp24909-cit-0029","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0166-2236(91)90168-T","article-title":"Ethical issues in brain-cell transplantation","volume":"14","author":"Hoffer","year":"1991","journal-title":"Trends Neurosci"},{"key":"10.1002\/jcp.24909-BIB0030|jcp24909-cit-0030","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/gt.2009.80","article-title":"Intrathecal transplantation of human neural stem cells over-expressing VEGF provides behavioral improvement, disease onset delay and survival extension in transgenic ALS mice","volume":"16","author":"Hwang","year":"2009","journal-title":"Gene Ther"},{"key":"10.1002\/jcp.24909-BIB0031|jcp24909-cit-0031","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.3727\/096368910X557155","article-title":"Combination of multifaceted strategies to maximize the therapeutic benefits of neural stem cell transplantation for spinal cord repair","volume":"20","author":"Hwang","year":"2011","journal-title":"Cell Transplant"},{"key":"10.1002\/jcp.24909-BIB0032|jcp24909-cit-0032","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3727\/000000007783464678","article-title":"Neural stem cells, neural progenitors, and neurotrophic factors","volume":"16","author":"Hsu","year":"2007","journal-title":"Cell Transplant"},{"key":"10.1002\/jcp.24909-BIB0033|jcp24909-cit-0033","doi-asserted-by":"crossref","first-page":"18117","DOI":"10.1073\/pnas.0408258102","article-title":"Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha\/CXC chemokine receptor 4 pathway","volume":"101","author":"Imitola","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/jcp.24909-BIB0034|jcp24909-cit-0034","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1634\/stemcells.2006-0409","article-title":"Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model","volume":"25","author":"Lee","year":"2007a","journal-title":"Stem Cells"},{"key":"10.1002\/jcp.24909-BIB0035|jcp24909-cit-0035","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1371\/journal.pone.0000156","article-title":"Human neural stem cells overexpressing VEGF provides neuroprotection, angiogenesis and functional recovery in mouse stroke model","volume":"1","author":"Lee","year":"2007b","journal-title":"PLoS ONE"},{"key":"10.1002\/jcp.24909-BIB0036|jcp24909-cit-0036","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/brain\/awm306","article-title":"Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke","volume":"131","author":"Lee","year":"2008","journal-title":"Brain"},{"key":"10.1002\/jcp.24909-BIB0037|jcp24909-cit-0037","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/gt.2009.51","article-title":"Human neural stem cells overexpressing glial cell line derived neurotrophic factor (GDNF) promote functional recovery and neuroprotection in experimental cerebral hemorrhage","volume":"16","author":"Lee","year":"2009","journal-title":"Gene Ther"},{"key":"10.1002\/jcp.24909-BIB0038|jcp24909-cit-0038","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1002\/jnr.22474","article-title":"Human neural stem cells genetically modified to overexpress BDNF promotes functional recovery and neuroprotection in mouse stroke model","volume":"88","author":"Lee","year":"2010","journal-title":"J Neurosci Res"},{"key":"10.1002\/jcp.24909-BIB0039|jcp24909-cit-0039","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1385\/JMN:24:3:353","article-title":"Embryonic and adult stem cells as a source for cell therapy in Parkinson's disease","volume":"24","author":"Levy","year":"2004","journal-title":"J Mol Neurosci"},{"key":"10.1002\/jcp.24909-BIB0040|jcp24909-cit-0040","doi-asserted-by":"crossref","first-page":"6639","DOI":"10.1523\/JNEUROSCI.22-15-06639.2002","article-title":"The adult substantia nigra contains progenitor cells with neurogenic potential","volume":"22","author":"Lie","year":"2002","journal-title":"J Neurosci"},{"key":"10.1002\/jcp.24909-BIB0041|jcp24909-cit-0041","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/foc.2002.13.5.3","article-title":"Role of cell therapy in Parkinson disease","volume":"13","author":"Lindvall","year":"2002","journal-title":"Neurosurg Focus"},{"key":"10.1002\/jcp.24909-BIB0042|jcp24909-cit-0042","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1038\/nm1064","article-title":"Stem cell therapy for human neurodegenerative disorders-how to make it work","volume":"10","author":"Lindvall","year":"2004a","journal-title":"Nat Med"},{"key":"10.1002\/jcp.24909-BIB0043|jcp24909-cit-0043","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1602\/neurorx.1.4.382","article-title":"Cell therapy in Parkinson's disease","volume":"1","author":"Lindvall","year":"2004b","journal-title":"NeuroRx"},{"key":"10.1002\/jcp.24909-BIB0044|jcp24909-cit-0044","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1126\/science.8493557","article-title":"GDNF: A glial cell line- derived neurotrophic factor for midbrain dopaminergic neurons","volume":"260","author":"Lin","year":"1993","journal-title":"Science"},{"key":"10.1002\/jcp.24909-BIB0045|jcp24909-cit-0045","first-page":"114-115","volume-title":"Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology","author":"Luna","year":"1968"},{"key":"10.1002\/jcp.24909-BIB0046|jcp24909-cit-0046","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/0006-8993(94)01366-P","article-title":"GDNF protects nigral dopamine neurons against 6- hydroxydopamine in vivo","volume":"672","author":"Kearns","year":"1995","journal-title":"Brain Res"},{"key":"10.1002\/jcp.24909-BIB0047|jcp24909-cit-0047","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0006-8993(88)91138-9","article-title":"Glutamate decarboxylase immunoreactive neurons in rat neostriatum: Their morphological types and populations","volume":"447","author":"Kita","year":"1988","journal-title":"Brain Res"},{"key":"10.1002\/jcp.24909-BIB0048|jcp24909-cit-0048","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1440-1789.2006.00688.x","article-title":"Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease","volume":"26","author":"Kim","year":"2006","journal-title":"Neuropathol"},{"key":"10.1002\/jcp.24909-BIB0049|jcp24909-cit-0049","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1002\/jnr.22054","article-title":"Stem cell-based cell therapy in neurological diseases: A review","volume":"87","author":"Kim","year":"2009","journal-title":"J Neurosci Res"},{"key":"10.1002\/jcp.24909-BIB0050|jcp24909-cit-0050","doi-asserted-by":"crossref","first-page":"e28420","DOI":"10.1371\/journal.pone.0028420","article-title":"Gene expression profiling of embryonic human neural stem cells and dopaminergic neurons from adult human substantia nigra","volume":"6","author":"Marei","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1002\/jcp.24909-BIB0051|jcp24909-cit-0051","doi-asserted-by":"crossref","first-page":"e33542","DOI":"10.1371\/journal.pone.0033542","article-title":"Gene expression profile of adult human olfactory bulb and embryonic neural stem cell suggests distinct signaling pathways and epigenetic control","volume":"7","author":"Marei","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1002\/jcp.24909-BIB0052|jcp24909-cit-0052","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ygeno.2012.09.006","article-title":"Transcription factors expressed in embryonic and adult olfactory bulb neural stem cells reveal distinct proliferation, differentiation and epigenetic control","volume":"101","author":"Marei","year":"2013","journal-title":"Genomics"},{"key":"10.1002\/jcp.24909-BIB0053|jcp24909-cit-0053","doi-asserted-by":"crossref","first-page":"e82206","DOI":"10.1371\/journal.pone.0082206","article-title":"Over-expression of hNGF in adult human olfactory bulb neural stem cells promotes cell growth and oligodendrocytic differentiation","volume":"8","author":"Marei","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1002\/jcp.24909-BIB0054|jcp24909-cit-0054","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24688","article-title":"Adult human olfactory bulb neural stem cells overexpression hNGF restore cognitive functional deficit in ibotenic acid-induced Alzheimer's disease rat model","author":"Marei","year":"2014","journal-title":"J Cell Physiol"},{"key":"10.1002\/jcp.24909-BIB0055|jcp24909-cit-0055","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S0166-2236(97)01119-3","article-title":"Immortalized neural progenitor cells for CNS gene transfer and repair","volume":"20","author":"Martinez-Serrano","year":"1997","journal-title":"Trends Neurosci"},{"key":"10.1002\/jcp.24909-BIB0056|jcp24909-cit-0056","first-page":"83","article-title":"Inflammation in Parkinson's disease","volume":"86","author":"McGeer","year":"2001","journal-title":"Adv Neurol"},{"key":"10.1002\/jcp.24909-BIB0057|jcp24909-cit-0057","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.brainres.2003.10.035","article-title":"6-hydroxydopamine increases the level of TNF\u03b1 and Bax mRNA in the striatum and induces apoptosis of dopaminergic neurons in hemi-parkinsonian rats","volume":"996","author":"Mladenovic","year":"2004","journal-title":"Brain Res"},{"key":"10.1002\/jcp.24909-BIB0058|jcp24909-cit-0058","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/01.EHX.0000424089.76006.d7","article-title":"Histological study on the effect of sodium azide on the corpus striatum of albino rats and the possible protective role of l-carnitine","volume":"36","author":"Mohamed","year":"2013","journal-title":"Egypt J Histol"},{"key":"10.1002\/jcp.24909-BIB0059|jcp24909-cit-0059","first-page":"435","article-title":"A simple quantitative bradykinesia test in MPTPtreated mice","volume":"50","author":"Ogawa","year":"1985","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"10.1002\/jcp.24909-BIB0060|jcp24909-cit-0060","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/nbt750","article-title":"Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons","volume":"20","author":"Ourednik","year":"2002","journal-title":"Nat Biotechnol"},{"key":"10.1002\/jcp.24909-BIB0061|jcp24909-cit-0061","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1634\/stemcells.18-4-295","article-title":"Isolation and characterization of neural stem cells from the adult human olfactory bulb","volume":"18","author":"Pagano","year":"2000","journal-title":"Stem Cells"},{"key":"10.1002\/jcp.24909-BIB0062|jcp24909-cit-0062","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/jcp.24442","article-title":"Induction of dopaminergic neurons from human Wharton's jelly mesenchymal stem cell by forskolin","volume":"229","author":"Paldino","year":"2014","journal-title":"J Cell Physiol"},{"key":"10.1002\/jcp.24909-BIB0063|jcp24909-cit-0063","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nbt751","article-title":"The injured brain interacts reciprocally with neural stem cells supported on scaffolds to reconstitute lost tissue","volume":"20","author":"Park","year":"2002","journal-title":"Nat Biotechnol"},{"key":"10.1002\/jcp.24909-BIB0064|jcp24909-cit-0064","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0165-0270(85)90026-3","article-title":"Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight","volume":"13","author":"Paxinos","year":"1985","journal-title":"Neurosci Methods"},{"key":"10.1002\/jcp.24909-BIB0065|jcp24909-cit-0065","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.1523\/JNEUROSCI.20-19-07297.2000","article-title":"Synaptic vesicle transporter expression regu lates vesicle phenotype and quantal size","volume":"20","author":"Pothos","year":"2000","journal-title":"J Neurosci"},{"key":"10.1002\/jcp.24909-BIB0066|jcp24909-cit-0066","doi-asserted-by":"crossref","first-page":"12175","DOI":"10.1073\/pnas.0704091104","article-title":"Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells","volume":"104","author":"Redmond","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/jcp.24909-BIB0067|jcp24909-cit-0067","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.1996.0090","article-title":"Clonal and population analyses demonstrate that an EGF responsive mammalian embryonic CNS precursor is a stem cell","volume":"175","author":"Reynolds","year":"1996","journal-title":"Dev Biol"},{"key":"10.1002\/jcp.24909-BIB0068|jcp24909-cit-0068","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.mcn.2004.11.013","article-title":"Heterotypic neuronal differentiation of adult subependymal zone neuronal progenitor cells transplanted to the adult hippocampus","volume":"28","author":"Richardson","year":"2005","journal-title":"Mol Cell Neurosci"},{"key":"10.1002\/jcp.24909-BIB0069|jcp24909-cit-0069","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2741\/2558","article-title":"Neural stem cell engineering: Directed differentiation of adult and embryonic stem cells into neurons","volume":"13","author":"Robertson","year":"2008","journal-title":"Front Biosci"},{"key":"10.1002\/jcp.24909-BIB0070|jcp24909-cit-0070","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1006\/exnr.1999.7296","article-title":"Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model","volume":"161","author":"Rosenblad","year":"2000","journal-title":"Exp Neurol"},{"key":"10.1002\/jcp.24909-BIB0071|jcp24909-cit-0071","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1046\/j.1460-9568.1999.00566.x","article-title":"Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle","volume":"11","author":"Rosenblad","year":"1999","journal-title":"Eur J Neurosci"},{"key":"10.1002\/jcp.24909-BIB0072|jcp24909-cit-0072","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0306-4522(94)90605-X","article-title":"Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat","volume":"59","author":"Sauer","year":"1994","journal-title":"Neuroscience"},{"key":"10.1002\/jcp.24909-BIB0073|jcp24909-cit-0073","doi-asserted-by":"crossref","first-page":"8935","DOI":"10.1073\/pnas.92.19.8935","article-title":"Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion","volume":"92","author":"Sauer","year":"1995","journal-title":"Procx Natl Acad Sci USA"},{"key":"10.1002\/jcp.24909-BIB0074|jcp24909-cit-0074","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/01.wco.0000174298.27765.91","article-title":"Stem cell treatment for Parkinson's disease","volume":"18","author":"Snyder","year":"2005","journal-title":"Curr Opin Neurol"},{"key":"10.1002\/jcp.24909-BIB0075|jcp24909-cit-0075","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/0959-4388(94)90018-3","article-title":"Grafting immortalized neurons to the CNS","volume":"4","author":"Snyder","year":"1994","journal-title":"Curr Opin Neurobiol"},{"key":"10.1002\/jcp.24909-BIB0076|jcp24909-cit-0076","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/cne.901950403","article-title":"Monosynaptic cortical input and local axon collaterals of identified striatonigral neurons. A light and electron microscopic study using the Golgi-peroxidase transport-degeneration procedure","volume":"195","author":"Somogyi","year":"1981","journal-title":"J Comp Neurol"},{"key":"10.1002\/jcp.24909-BIB0077|jcp24909-cit-0077","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.molbrainres.2004.09.002","article-title":"Stem cells may reshape the prospect of Parkinson's disease therapy","volume":"134","author":"Sonntag","year":"2005","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1002\/jcp.24909-BIB0078|jcp24909-cit-0078","first-page":"311","article-title":"Potential use of neurotrophic agents in the treatment of neurodegenerative disorders","volume":"50","author":"Tuszy\u0144ski","year":"1990","journal-title":"Acta Neurobiol Exp"},{"key":"10.1002\/jcp.24909-BIB0079|jcp24909-cit-0079","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/ana.410300502","article-title":"Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain","volume":"30","author":"Tuszynski","year":"1991","journal-title":"Ann Neurol"},{"key":"10.1002\/jcp.24909-BIB0080|jcp24909-cit-0080","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0006-8993(70)90187-3","article-title":"Quantitational recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system","volume":"24","author":"Ungerstedt","year":"1970","journal-title":"Brain Res"},{"key":"10.1002\/jcp.24909-BIB0081|jcp24909-cit-0081","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/exnr.1999.7237","article-title":"Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS","volume":"161","author":"Villa","year":"2000","journal-title":"Exp Neurol"},{"key":"10.1002\/jcp.24909-BIB0082|jcp24909-cit-0082","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000071817","article-title":"GDNF acutely potentiates Ca2+ channels and excitatory synaptic transmission in midbrain dopaminergic neurons","volume":"12","author":"Wang","year":"2003","journal-title":"Neuro signals"},{"key":"10.1002\/jcp.24909-BIB0083|jcp24909-cit-0083","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF02740745","article-title":"Physiological relevance and functional potential of central nervous system-derived cell lines","volume":"12","author":"Whittemore","year":"1996","journal-title":"Mol Neurobiol"},{"key":"10.1002\/jcp.24909-BIB0084|jcp24909-cit-0084","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/cne.901940308","article-title":"Fine structure and synaptic connections of the common spiny neuron of the rat neostriatum: A study employing intracellular inject of horseradish peroxidase","volume":"194","author":"Wilson","year":"1980","journal-title":"J Comp Neurol"},{"key":"10.1002\/jcp.24909-BIB0085|jcp24909-cit-0085","doi-asserted-by":"crossref","first-page":"7206","DOI":"10.1523\/JNEUROSCI.16-22-07206.1996","article-title":"Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease","volume":"16","author":"Winkler","year":"1996","journal-title":"J Neurosci"},{"key":"10.1002\/jcp.24909-BIB0086|jcp24909-cit-0086","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.neulet.2008.05.107","article-title":"BDNF improves the effects of neural stem cells on the rat model of Alzheimer's disease with unilateral lesion of fimbria-fornix","volume":"440","author":"Xuan","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1002\/jcp.24909-BIB0087|jcp24909-cit-0087","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nn734","article-title":"GDNF acutely modulates excitability and A-type K(+) channels in midbrain dopaminergic neurons","volume":"4","author":"Yang","year":"2001","journal-title":"Nat Neurosci"},{"key":"10.1002\/jcp.24909-BIB0088|jcp24909-cit-0088","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jneumeth.2004.10.004","article-title":"Histological, behavioural and neurochemical evaluation of medial forebrain bundle and striatal 6-OHDA lesions as rat models of Parkinson's disease","volume":"144","author":"Yuan","year":"2005","journal-title":"J Neurosci Methods"},{"key":"10.1002\/jcp.24909-BIB0089|jcp24909-cit-0089","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nbt1201-1129","article-title":"In vitro differentiation of transplantable neural precursors from human embryonic stem cells","volume":"19","author":"Zhang","year":"2002","journal-title":"Nat Biotech"},{"key":"10.1002\/jcp.24909-BIB0090|jcp24909-cit-0090","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1089\/scd.2006.15.943","article-title":"Oligodendrocyte progenitor cells derived from human embryonic stem cells express neurotrophic factors","volume":"15","author":"Zhang","year":"2006","journal-title":"Stem Cells Dev"},{"key":"10.1002\/jcp.24909-BIB0091|jcp24909-cit-0091","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/1096-9861(20001120)427:3<440::AID-CNE10>3.0.CO;2-7","article-title":"Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion","volume":"427","author":"Zuch","year":"2000","journal-title":"J Comp Neurol"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.24909","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.24909","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/jcp.24909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T12:01:06Z","timestamp":1625313666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.24909"}},"subtitle":["OLFACTORY BULB NSC MITIGATE PD"],"short-title":[],"issued":{"date-parts":[[2015,3,27]]},"references-count":91,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"URL":"https:\/\/doi.org\/10.1002\/jcp.24909","archive":["Portico"],"relation":{},"ISSN":["0021-9541"],"issn-type":[{"value":"0021-9541","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3,27]]}}}