{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:01:35Z","timestamp":1790499695156,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T00:00:00Z","timestamp":1432598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National 973 Projects","award":["2009CB522102"],"award-info":[{"award-number":["2009CB522102"]}]},{"name":"National 973 Projects","award":["2013CB967404"],"award-info":[{"award-number":["2013CB967404"]}]},{"name":"National 973 Projects","award":["2013CB967401"],"award-info":[{"award-number":["2013CB967401"]}]},{"name":"National 973 Projects","award":["2010CB945403"],"award-info":[{"award-number":["2010CB945403"]}]},{"name":"National 973 Projects","award":["2013CB967403"],"award-info":[{"award-number":["2013CB967403"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["31071019"],"award-info":[{"award-number":["31071019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["31140034"],"award-info":[{"award-number":["31140034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Focused Investment Scheme of the Chinese University of Hong Kong"},{"name":"Hong Kong University Grants Committee","award":["GRF\/CUHK\/466111"],"award-info":[{"award-number":["GRF\/CUHK\/466111"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>The physiological role of cystic fibrosis transmembrane conductance regulator (CFTR) in keratinocytes and skin wound healing is completely unknown. The present study shows that CFTR is expressed in the multiple layers of keratinocytes in mouse epidermis and exhibits a dynamic expression pattern in a dorsal skin wound healing model, with diminishing levels observed from day 3 to day 5 and re\u2010appearing from day 7 to day 10 after wounding. Knockdown of CFTR in cultured human keratinocytes promotes cell migration but inhibits differentiation, while overexpression of CFTR suppresses migration but enhances differentiation, indicating an important role of CFTR in regulating keratinocyte behavior. In addition, we have demonstrated a direct association of CFTR with epithelial junction formation as knockdown of CFTR downregulates the expression of adhesion molecules, such as E\u2010cadherin, ZO\u20101 and \u03b2\u2010catenin, and disrupts the formation of cell junction, while overexpression of CFTR enhances cell junction formation. More importantly, we have shown that \u0394F508<jats:italic>cftr<\/jats:italic>\u2212\/\u2212 mice with defective CFTR exhibit delayed wound healing as compared to wild type mice, indicating that normal function of CFTR is critical for wound repair. Taken together, the present study has revealed a previously undefined role of CFTR in regulating skin wound healing processes, which may have implications in injury repair of other epithelial tissues. J. Cell. Physiol. 230: 2049\u20132058, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.24931","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T21:42:07Z","timestamp":1422567727000},"page":"2049-2058","source":"Crossref","is-referenced-by-count":25,"title":["Dynamically Regulated CFTR Expression and Its Functional Role in Cutaneous Wound Healing"],"prefix":"10.1002","volume":"230","author":[{"given":"Jianda","family":"Dong","sequence":"first","affiliation":[{"name":"School of Life Sciences Sun Yat\u2010sen University Guangzhou China"},{"name":"Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine, The Chinese University of Hong Kong Sha Tin NT Hong Kong"},{"name":"Key Laboratory of Reproduction and Genetic of Ningxia Hui Autonomous Region Key Laboratory of Fertility Preservation and Maintenance of Ningxia Medical University and Ministry of Education of China Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine, The Chinese University of Hong Kong Sha Tin NT Hong Kong"},{"name":"Key Laboratory for Regenerative Medicine (Ji Nan University \u2013 The Chinese University of Hong Kong) Ministry of Education of the People's Republic of China China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine, The Chinese University of Hong Kong Sha Tin NT Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai Sheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine, The Chinese University of Hong Kong Sha Tin NT Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine, The Chinese University of Hong Kong Sha Tin NT Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine, The Chinese University of Hong Kong Sha Tin NT Hong Kong"},{"name":"Sichuan University \u2013 The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine West China Second University Hospital Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Kuen","family":"Yu","sequence":"additional","affiliation":[{"name":"Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine, The Chinese University of Hong Kong Sha Tin NT Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai Ling","family":"Tsang","sequence":"additional","affiliation":[{"name":"Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine, The Chinese University of Hong Kong Sha Tin NT Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiu Wa","family":"Chung","sequence":"additional","affiliation":[{"name":"Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine, The Chinese University of Hong Kong Sha Tin NT Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrong","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Reproduction and Genetic of Ningxia Hui Autonomous Region Key Laboratory of Fertility Preservation and Maintenance of Ningxia Medical University and Ministry of Education of China Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010liang","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao Chang","family":"Chan","sequence":"additional","affiliation":[{"name":"Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine, The Chinese University of Hong Kong Sha Tin NT Hong Kong"},{"name":"Key Laboratory for Regenerative Medicine (Ji Nan University \u2013 The Chinese University of Hong Kong) Ministry of Education of the People's Republic of China China"},{"name":"Sichuan University \u2013 The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine West China Second University Hospital Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00554.2002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2012.123"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12345083"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1363"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.23020"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1375392"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/358708a0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.5.8912731"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1734-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2118"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119828"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.06.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11294"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00313.2010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2010.07.010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2012.88"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05438.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5309.75"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12612810"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.10.033"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19601.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00215.2010"},{"key":"e_1_2_7_24_1","first-page":"L405","article-title":"Expression of cystic fibrosis transmembrane conductance regulator in a model epithelium","volume":"266","author":"Sheppard DN","year":"1994","journal-title":"Am J Physiol"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411006"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.12.013"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.12.013"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.23.2.4214"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00221711"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90224.2008"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2006.12.001"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5277"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12395564"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/359195a0"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.07.021"},{"key":"e_1_2_7_36_1","doi-asserted-by":"crossref","first-page":"15584","DOI":"10.1016\/S0021-9258(19)37628-8","article-title":"The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences","volume":"263","author":"Zhou XM","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg595"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.24931","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.24931","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.24931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T07:52:50Z","timestamp":1728287570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.24931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,26]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1002\/jcp.24931"],"URL":"https:\/\/doi.org\/10.1002\/jcp.24931","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,26]]}}}