{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:49:45Z","timestamp":1788871785103,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31200862"],"award-info":[{"award-number":["31200862"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Apoptosis of cardiomyocytes plays an important role in the transition from cardiac hypertrophy to heart failure. Hypertrophied cardiomyocytes show enhanced susceptibility to apoptosis. Therefore, the aim of this study was to determine the susceptibility to apoptosis and its mechanism in hypertrophied cardiomyocytes using a rat model of transverse abdominal aortic constriction (TAC). Sixteen weeks of TAC showed compensatory and pathological hypertrophy in the left ventricle. TUNEL\u2010positive nuclei were significantly increased in TAC with angiotensin II (Ang II) treatment. Calpain inhibitor, PD150606, effectively inhibited Ang II\u2010induced apoptosis of hypertrophied cardiomyocytes. Ang II increased nuclear translocation of intracellular Ca\n                      <jats:sup>2+<\/jats:sup>\n                      activated calpain\u20102 in hypertrophied cardiomyocytes. Ang II enhanced the interaction between activated calpain\u20102 and Ca\n                      <jats:sup>2+<\/jats:sup>\n                      \/calmodulin\u2010dependent protein kinase II \u03b4B (CaMKII\u03b4B), and promoted the degradation of CaMKII\u03b4B by calpain\u20102 in the nuclei of hypertrophied cardiomyocytes. Consequently, the depressed CaMKII\u03b4B downregulated the expression of antiapoptotic Bcl\u20102 leading to mitochondrial depolarization and release of cytochrome c led to apoptosis of hypertrophied cardiomyocytes. In conclusion, hypertrophied cardiomyocytes show increased susceptibility to apoptosis during Ang II stimulation via nuclear calpain\u20102 and CaMKII\u03b4B pathway. J. Cell. Physiol. 9999: 2743\u20132754, 2015. \u00a9 2015 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.24999","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T18:15:19Z","timestamp":1427480119000},"page":"2743-2754","source":"Crossref","is-referenced-by-count":13,"title":["Nuclear Translocation of Calpain\u20102 Mediates Apoptosis of Hypertrophied Cardiomyocytes in Transverse Aortic Constriction Rat"],"prefix":"10.1002","volume":"230","author":[{"given":"Juan\u2010Juan","family":"Sheng","sequence":"first","affiliation":[{"name":"Department of Aerospace Physiology Fourth Military Medical University 169# Changlexi Road Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Aerospace Physiology Fourth Military Medical University 169# Changlexi Road Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Bin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Aerospace Physiology Fourth Military Medical University 169# Changlexi Road Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006857213829"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/8385"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.05.059"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301738200"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000156458.80515.F7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22947"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103701200"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.23.3071"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1997.0524"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000164237.58200.5A"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-0025"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(00)00256-6"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000261938.28365.11"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00071.2007"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.02.017"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002231"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(92)90033-5"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.160077"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs099"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp189"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.272.5.H2313"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.003186"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-0816-3"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.114090"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.210914"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.229393"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12295"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.73.3.439"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn289"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-012-1325-8"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00026.2012"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2012.01536.x"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.24999","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.24999","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T03:45:13Z","timestamp":1728272713000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.24999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,27]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/jcp.24999"],"URL":"https:\/\/doi.org\/10.1002\/jcp.24999","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,27]]}}}