{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:04:15Z","timestamp":1774983855887,"version":"3.50.1"},"reference-count":159,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:label\/><jats:p>It is increasingly recognized that immunomodulation represents an important mechanism underlying the benefits of many stem cell therapies, rather than the classical paradigm of transdifferentiation and cell replacement. In the former paradigm, the beneficial effects of cell therapy result from paracrine mechanism(s) and\/or cell\u2013cell interaction as opposed to direct engraftment and repair of diseased tissue and\/or dysfunctional organs. Depending on the cell type used, components of the secretome, including microRNA (miRNA) and extracellular vesicles, may be able to either activate or suppress the immune system even without direct immune cell contact. Mesenchymal stromal cells (MSCs), also referred to as mesenchymal stem cells, are found not only in the bone marrow, but also in a wide variety of organs and tissues. In addition to any direct stem cell activities, MSCs were the first stem cells recognized to modulate immune response, and therefore they will be the focus of this review. Specifically, MSCs appear to be able to effectively attenuate acute and protracted inflammation via interactions with components of both innate and adaptive immune systems. To date, this capacity has been exploited in a large number of preclinical studies and MSC immunomodulatory therapy has been attempted with various degrees of success in a relatively large number of clinical trials. Here, we will explore the various mechanism employed by MSCs to effect immunosuppression as well as review the current status of its use to treat excessive inflammation in the context of acute lung injury (ALI) and sepsis in both preclinical and clinical settings. J. Cell. Physiol. 9999: 2606\u20132617, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.25028","type":"journal-article","created":{"date-parts":[[2015,4,25]],"date-time":"2015-04-25T12:02:59Z","timestamp":1429963379000},"page":"2606-2617","source":"Crossref","is-referenced-by-count":83,"title":["The Immunomodulatory and Therapeutic Effects of Mesenchymal Stromal Cells for Acute Lung Injury and Sepsis"],"prefix":"10.1002","volume":"230","author":[{"given":"Mirabelle S. H.","family":"Ho","sequence":"first","affiliation":[{"name":"Sinclair Centre for Regenerative Medicine Ottawa Hospital Research Institute Ottawa Ontario"},{"name":"Department of Cellular and Molecular Medicine Faculty of Medicine University of Ottawa Ottawa Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley H. J.","family":"Mei","sequence":"additional","affiliation":[{"name":"Sinclair Centre for Regenerative Medicine Ottawa Hospital Research Institute Ottawa Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duncan J.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Sinclair Centre for Regenerative Medicine Ottawa Hospital Research Institute Ottawa Ontario"},{"name":"Department of Cellular and Molecular Medicine Faculty of Medicine University of Ottawa Ottawa Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1559"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.150.8.3109"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-014-9545-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208623"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.2001.680412.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200902-0242OC"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00396.2001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72181"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1977.116.4.589"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.247395"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2012.04.005"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/10430340152480258"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(01)00769-X"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.071"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2000.0348"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00297-2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0068"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.09.006"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_7_22_1","first-page":"442","article-title":"Use of cyclophosphamide and other immunosuppressive drugs in the treatment of patients with lupus nephritis","volume":"69","author":"Brugos B","year":"2014","journal-title":"Pharmazie"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1854"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2013.135"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-327353"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm740"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2657"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.191643"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.07.003"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199508000-00019"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(00)00482-3"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2008.0630"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00182"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3838"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201201-0003OC"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240600855905"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.08.009"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.215152"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01986.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.119917"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2682-1"},{"key":"e_1_2_7_42_1","first-page":"2526","article-title":"Acute respiratory distress syndrome: The Berlin definition","volume":"307","author":"Force ADT","year":"2012","journal-title":"JAMA"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1993.1177"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00256.2006"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-196803000-00009"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62575-8"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.7.603"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205121200"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3696"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300290110"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2011.04.004"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.3.1855"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1270"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003023420901"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00205.2003"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911027107"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021333"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104762"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0189"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000158"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2736"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0586"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2013.06.002"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-12-157"},{"key":"e_1_2_7_65_1","first-page":"223","article-title":"Th1\/Th2 balance: The hypothesis, its limitations, and implications for health and disease","volume":"8","author":"Kidd P","year":"2003","journal-title":"Altern Med Rev"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2009.09.004"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.22443"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.12.005"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0931"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030212-183809"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2104"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0008"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00378-6"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2009.12.003"},{"key":"e_1_2_7_75_1","first-page":"557","article-title":"Ex vivo expansion and subsequent infusion of human bone marrow\u2010derived stromal progenitor cells (mesenchymal progenitor cells): Implications for therapeutic use","volume":"16","author":"Lazarus HM","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3209"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2003.01176.x"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01250.x"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.116.2.545"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907996106"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2009.05.003"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.643"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290323"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2014.01.008"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-014-0022-z"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1153"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1758"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4133"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.F305"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60331"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200609-1370OC"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040269"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201001-0010OC"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.57"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0340446"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200012)43:12<2668::AID-ANR6>3.0.CO;2-E"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196306132682401"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062200"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.4.2080"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1905"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012835"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.035"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00635.x"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1012451107"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.7"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704421104"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-4-20"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000941"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-94"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200508-1302OC"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/321602"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2014.06.004"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5411.143"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705259"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200738129"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11240"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.211"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-534297"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-166892"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.12.005"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.11.014"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.05.017"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8411(03)00047-7"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365051"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050333"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.144.5.1767"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043632"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03422.x"},{"key":"e_1_2_7_129_1","doi-asserted-by":"publisher","DOI":"10.1080\/078538902321117797"},{"key":"e_1_2_7_130_1","article-title":"Therapeutic MSC exosomes are derived from lipid raft microdomains in the plasma membrane","volume":"2","author":"Tan SS","year":"2013","journal-title":"J Extracell Vesicles"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8342023"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1244"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5449.2511"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2008.02.002"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0563"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000045055.63901.A9"},{"key":"e_1_2_7_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11707"},{"key":"e_1_2_7_138_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12464"},{"key":"e_1_2_7_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22236"},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819cedfd"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300891"},{"key":"e_1_2_7_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.04.010"},{"key":"e_1_2_7_143_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-5-19"},{"key":"e_1_2_7_144_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421806"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.6.2004035"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010088"},{"key":"e_1_2_7_147_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1985.01390290018003"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243147"},{"key":"e_1_2_7_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70291-7"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.11.6593"},{"key":"e_1_2_7_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2302"},{"key":"e_1_2_7_152_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2009.41.5.035"},{"key":"e_1_2_7_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.07.001"},{"key":"e_1_2_7_154_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000133332.48386.85"},{"key":"e_1_2_7_155_1","first-page":"109","article-title":"Transplantation of umbilical cord mesenchymal stem cells alleviates pneumonitis of MRL\/lpr mice","volume":"6","author":"Zhang Y","year":"2014","journal-title":"J Thorac Dis"},{"key":"e_1_2_7_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-015-0805-1"},{"key":"e_1_2_7_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2003.11.009"},{"key":"e_1_2_7_158_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-15-39"},{"key":"e_1_2_7_159_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1504"},{"key":"e_1_2_7_160_1","doi-asserted-by":"publisher","DOI":"10.1089\/107632701300062859"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.25028","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.25028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T07:46:59Z","timestamp":1728287219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.25028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,27]]},"references-count":159,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/jcp.25028"],"URL":"https:\/\/doi.org\/10.1002\/jcp.25028","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,27]]}}}