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The present study used in vivo and in vitro approaches to explore the effects of LaCl<jats:sub>3<\/jats:sub> on osteoclasts and osteolysis. The results indicated that LaCl<jats:sub>3<\/jats:sub> concentrations that were non\u2010cytotoxic to mouse bone marrow\u2010derived monocytes attenuated receptor activator of nuclear factor\u2010\u03baB ligand (RANKL)\u2010stimulated osteoclastogenesis, bone resorption, mRNA expression of osteoclastogenic genes in these cells, including cathepsin K, calcitonin receptor, and tartrate\u2010resistant acid phosphatase (TRAP). Further, LaCl<jats:sub>3<\/jats:sub> inhibited RANKL\u2010mediated activation of the nuclear factor\u2010\u03baB (NF\u2010\u03baB) signaling pathway, and downregulated mRNA and protein levels of nuclear factor of activated T\u2010cells, cytoplasmic, calcineurin\u2010dependent 1 (NFATc1), and c\u2010fos. In vivo, LaCl<jats:sub>3<\/jats:sub> attenuated titanium (Ti) particle\u2010induced bone loss in a murine calvarial osteolysis model. Histological analyses revealed that LaCl<jats:sub>3<\/jats:sub> ameliorated bone destruction and decreased the number of TRAP\u2010positive osteoclasts in this model. These results demonstrated that LaCl<jats:sub>3<\/jats:sub> inhibited osteoclast formation, function, and osteoclast\u2010specific gene expression in vitro, and attenuated Ti particle\u2010induced mouse calvarial osteolysis in vivo, where the inhibition of NF\u2010\u03baB signaling and downregulation of NFATc1 and c\u2010fos played an important role. J. Cell. Physiol. 230: 142\u2013151, 2016. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.25065","type":"journal-article","created":{"date-parts":[[2015,6,9]],"date-time":"2015-06-09T16:50:05Z","timestamp":1433868605000},"page":"142-151","source":"Crossref","is-referenced-by-count":36,"title":["Lanthanum Chloride Attenuates Osteoclast Formation and Function Via the Downregulation of Rankl\u2010Induced Nf\u2010\u03bab and Nfatc1 Activities"],"prefix":"10.1002","volume":"231","author":[{"given":"Chuan","family":"Jiang","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyinzi","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital Nanchang University Nanchang 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