{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T18:36:37Z","timestamp":1758393397111,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"American Heart Association-Grant-in-Aid","award":["14GRNT20490320"],"award-info":[{"award-number":["14GRNT20490320"]}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["N81370192"],"award-info":[{"award-number":["N81370192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Cell. Physiol."],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1002\/jcp.25275","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T13:28:40Z","timestamp":1449062920000},"page":"1737-1744","source":"Crossref","is-referenced-by-count":14,"title":["Thymosin \u03b24 Prevents Angiotensin II-Induced Cardiomyocyte Growth by Regulating Wnt\/WISP Signaling"],"prefix":"10.1002","volume":"231","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[{"name":"Division of Molecular Cardiology, Department of Medicine, College of Medicine; Texas A&M Health Science Center; Temple Texas"},{"name":"Baylor Scott and White Health; Temple Texas"},{"name":"Central Texas Veterans Health Care System; Temple Texas"},{"name":"Department of Physiology and Pathophysiology; Peking University Health Science Center; Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakeshwar S.","family":"Guleria","sequence":"additional","affiliation":[{"name":"Division of Molecular Cardiology, Department of Medicine, College of Medicine; Texas A&M Health Science Center; Temple Texas"},{"name":"Baylor Scott and White Health; Temple Texas"},{"name":"Central Texas Veterans Health Care System; Temple Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh","family":"Thakur","sequence":"additional","affiliation":[{"name":"Division of Molecular Cardiology, Department of Medicine, College of Medicine; Texas A&M Health Science Center; Temple Texas"},{"name":"Baylor Scott and White Health; Temple Texas"},{"name":"Central Texas Veterans Health Care System; Temple Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology; Peking University Health Science Center; Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Pan","sequence":"additional","affiliation":[{"name":"Division of Molecular Cardiology, Department of Medicine, College of Medicine; Texas A&M Health Science Center; Temple Texas"},{"name":"Baylor Scott and White Health; Temple Texas"},{"name":"Central Texas Veterans Health Care System; Temple Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth M.","family":"Baker","sequence":"additional","affiliation":[{"name":"Division of Molecular Cardiology, Department of Medicine, College of Medicine; Texas A&M Health Science Center; Temple Texas"},{"name":"Baylor Scott and White Health; Temple Texas"},{"name":"Central Texas Veterans Health Care System; Temple Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhiranjan","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Molecular Cardiology, Department of Medicine, College of Medicine; Texas A&M Health Science Center; Temple Texas"},{"name":"Baylor Scott and White Health; Temple Texas"},{"name":"Central Texas Veterans Health Care System; Temple Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,16]]},"reference":[{"key":"10.1002\/jcp.25275-BIB0001|jcp25275-cit-0001","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1161\/01.RES.0000266605.63681.5a","article-title":"Beta-catenin downregulation is required for adaptive cardiac remodeling","volume":"100","author":"Baurand","year":"2007","journal-title":"Circ Res"},{"key":"10.1002\/jcp.25275-BIB0002|jcp25275-cit-0002","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/CIRCRESAHA.110.223768","article-title":"WNT signaling in adult cardiac hypertrophy and remodeling: Lessons learned from cardiac development","volume":"107","author":"Bergmann","year":"2010","journal-title":"Circ Res"},{"key":"10.1002\/jcp.25275-BIB0003|jcp25275-cit-0003","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1172\/JCI31044","article-title":"ECM remodeling in hypertensive heart disease","volume":"117","author":"Berk","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1002\/jcp.25275-BIB0004|jcp25275-cit-0004","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nm0597-541","article-title":"A homologue of drosophila tissue polarity gene frizzled is expressed in migrating myofibroblasts in the infarcted rat heart","volume":"3","author":"Blankesteijn","year":"1997","journal-title":"Nat Med"},{"key":"10.1002\/jcp.25275-BIB0005|jcp25275-cit-0005","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature03000","article-title":"Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair","volume":"432","author":"Bock-Marquette","year":"2004","journal-title":"Nature"},{"key":"10.1002\/jcp.25275-BIB0006|jcp25275-cit-0006","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.cardiores.2006.06.025","article-title":"The role of Wnt signaling in cardiac development and tissue remodelling in the mature heart","volume":"72","author":"Brade","year":"2006","journal-title":"Cardiovasc Res"},{"key":"10.1002\/jcp.25275-BIB0007|jcp25275-cit-0007","doi-asserted-by":"crossref","first-page":"H1839","DOI":"10.1152\/ajpheart.00428.2007","article-title":"Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor","volume":"293","author":"Colston","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1002\/jcp.25275-BIB0008|jcp25275-cit-0008","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1749-6632.2010.05492.x","article-title":"Thymosin beta4: Structure, function, and biological properties supporting current and future clinical applications","volume":"1194","author":"Crockford","year":"2010","journal-title":"Ann NY Acad Sci"},{"key":"10.1002\/jcp.25275-BIB0009|jcp25275-cit-0009","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCRESAHA.110.232306","article-title":"Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure","volume":"108","author":"Dai","year":"2011","journal-title":"Circ Res"},{"key":"10.1002\/jcp.25275-BIB0010|jcp25275-cit-0010","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1113\/jphysiol.2012.235382","article-title":"Role of the wnt-frizzled system in cardiac pathophysiology: A rapidly developing, poorly understood area with enormous potential","volume":"591","author":"Dawson","year":"2013","journal-title":"J Physiol"},{"key":"10.1002\/jcp.25275-BIB0011|jcp25275-cit-0011","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0002-9440(10)63348-2","article-title":"WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair","volume":"165","author":"French","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1002\/jcp.25275-BIB0012|jcp25275-cit-0012","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","article-title":"Cardiac hypertrophy: The good, the bad, and the ugly","volume":"65","author":"Frey","year":"2003","journal-title":"Annu Rev Physiol"},{"key":"10.1002\/jcp.25275-BIB0013|jcp25275-cit-0013","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1083\/jcb.200207149","article-title":"Activation of nuclear factor-kappaB is necessary for myotrophin-induced cardiac hypertrophy","volume":"159","author":"Gupta","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1002\/jcp.25275-BIB0014|jcp25275-cit-0014","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMra072139","article-title":"Cardiac plasticity","volume":"358","author":"Hill","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1002\/jcp.25275-BIB0015|jcp25275-cit-0015","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1161\/CIRCULATIONAHA.107.758904","article-title":"Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection","volume":"117","author":"Hinkel","year":"2008","journal-title":"Circulation"},{"key":"10.1002\/jcp.25275-BIB0016|jcp25275-cit-0016","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/B978-0-12-386035-4.00002-1","article-title":"New insights into the mechanism of Wnt signaling pathway activation","volume":"291","author":"Kikuchi","year":"2011","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1002\/jcp.25275-BIB0017|jcp25275-cit-0017","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1161\/CIRCRESAHA.113.302095","article-title":"Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes","volume":"113","author":"Kolwicz","year":"2013","journal-title":"Circ Res"},{"key":"10.1002\/jcp.25275-BIB0018|jcp25275-cit-0018","doi-asserted-by":"crossref","first-page":"e26912","DOI":"10.1371\/journal.pone.0026912","article-title":"Thymosin beta 4 prevents oxidative stress by targeting antioxidant and anti-apoptotic genes in cardiac fibroblasts","volume":"6","author":"Kumar","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1002\/jcp.25275-BIB0019|jcp25275-cit-0019","doi-asserted-by":"crossref","first-page":"H1655","DOI":"10.1152\/ajpheart.00756.2011","article-title":"Cardiac-specific genetic inhibition of nuclear factor-kappaB prevents right ventricular hypertrophy induced by monocrotaline","volume":"302","author":"Kumar","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1002\/jcp.25275-BIB0020|jcp25275-cit-0020","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/HYPERTENSIONAHA.109.141127","article-title":"Wnt signaling is critical for maladaptive cardiac hypertrophy and accelerates myocardial remodeling","volume":"55","author":"Malekar","year":"2010","journal-title":"Hypertension"},{"key":"10.1002\/jcp.25275-BIB0021|jcp25275-cit-0021","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1096\/fasebj.11.6.9194528","article-title":"Thymosin beta 4 stimulates directional migration of human umbilical vein endothelial cells","volume":"11","author":"Malinda","year":"1997","journal-title":"FASEB J"},{"key":"10.1002\/jcp.25275-BIB0022|jcp25275-cit-0022","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1161\/01.HYP.36.4.501","article-title":"Leptin attenuates cardiac contraction in rat ventricular myocytes. Role of NO","volume":"36","author":"Nickola","year":"2000","journal-title":"Hypertension"},{"key":"10.1002\/jcp.25275-BIB0023|jcp25275-cit-0023","doi-asserted-by":"crossref","first-page":"H741","DOI":"10.1152\/ajpheart.00129.2014","article-title":"Thymosin-beta4 prevents cardiac rupture and improves cardiac function in mice with myocardial infarction","volume":"307","author":"Peng","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1002\/jcp.25275-BIB0024|jcp25275-cit-0024","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/FJC.0b013e318199f326","article-title":"Thymosin beta4 induces endothelial progenitor cell migration via PI3K\/Akt\/eNOS signal transduction pathway","volume":"53","author":"Qiu","year":"2009","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1002\/jcp.25275-BIB0025|jcp25275-cit-0025","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1161\/CIRCRESAHA.110.219840","article-title":"An updated overview on Wnt signaling pathways: A prelude for more","volume":"106","author":"Rao","year":"2010","journal-title":"Circ Res"},{"key":"10.1002\/jcp.25275-BIB0026|jcp25275-cit-0026","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/bbrc.1998.9607","article-title":"Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7","volume":"252","author":"Sagara","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/jcp.25275-BIB0027|jcp25275-cit-0027","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/01.RES.59.5.551","article-title":"Alpha-skeletal muscle actin mRNA's accumulate in hypertrophied adult rat hearts","volume":"59","author":"Schwartz","year":"1986","journal-title":"Circ Res"},{"key":"10.1002\/jcp.25275-BIB0028|jcp25275-cit-0028","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1749-6632.2010.05478.x","article-title":"Thymosin beta4 facilitates epicardial neovascularization of the injured adult heart","volume":"1194","author":"Smart","year":"2010","journal-title":"Ann NY Acad Sci"},{"key":"10.1002\/jcp.25275-BIB0029|jcp25275-cit-0029","doi-asserted-by":"crossref","first-page":"e20184","DOI":"10.1371\/journal.pone.0020184","article-title":"Significance of thymosin beta4 and implication of PINCH-1-ILK-alpha-parvin (PIP) complex in human dilated cardiomyopathy","volume":"6","author":"Sopko","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1002\/jcp.25275-BIB0030|jcp25275-cit-0030","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1101\/gad.942902","article-title":"WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase","volume":"16","author":"Su","year":"2002","journal-title":"Genes Dev"},{"key":"10.1002\/jcp.25275-BIB0031|jcp25275-cit-0031","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1748-1716.2011.02309.x","article-title":"The Wnt\/Frizzled pathway as a therapeutic target for cardiac hypertrophy: Where do we stand","volume":"204","author":"ter Horst","year":"2012","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1002\/jcp.25275-BIB0032|jcp25275-cit-0032","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1101\/gad.871501","article-title":"Wnt signals from the neural tube block ectopic cardiogenesis","volume":"15","author":"Tzahor","year":"2001","journal-title":"Genes Dev"},{"key":"10.1002\/jcp.25275-BIB0033|jcp25275-cit-0033","doi-asserted-by":"crossref","first-page":"14414","DOI":"10.1074\/jbc.M809757200","article-title":"WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death","volume":"284","author":"Venkatachalam","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1002\/jcp.25275-BIB0034|jcp25275-cit-0034","doi-asserted-by":"crossref","first-page":"e42586","DOI":"10.1371\/journal.pone.0042586","article-title":"Thymosin beta 4 protects cardiomyocytes from oxidative stress by targeting anti-oxidative enzymes and anti-apoptotic genes","volume":"7","author":"Wei","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1002\/jcp.25275-BIB0035|jcp25275-cit-0035","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3109\/10715762.2013.865839","article-title":"NF-kappaB mediated miR-21 regulation in cardiomyocytes apoptosis under oxidative stress","volume":"48","author":"Wei","year":"2014","journal-title":"Free Radic Res"},{"key":"10.1002\/jcp.25275-BIB0036|jcp25275-cit-0036","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.gene.2013.05.024","article-title":"Heat shock transcription factor 1 attenuates TNFalpha-induced cardiomyocyte death through suppression of NFkappaB pathway","volume":"527","author":"Wu","year":"2013","journal-title":"Gene"},{"key":"10.1002\/jcp.25275-BIB0037|jcp25275-cit-0037","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1101\/gad.14.5.585","article-title":"WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene","volume":"14","author":"Xu","year":"2000","journal-title":"Genes Dev"},{"key":"10.1002\/jcp.25275-BIB0038|jcp25275-cit-0038","doi-asserted-by":"crossref","first-page":"19762","DOI":"10.1073\/pnas.0808393105","article-title":"Beta-Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation","volume":"105","author":"Zelarayan","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/jcp.25275-BIB0039|jcp25275-cit-0039","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1161\/HYPERTENSIONAHA.109.143297","article-title":"Wnt signaling molecules in left ventricular remodeling: Focus on dishevelled 1","volume":"55","author":"Zelarayan","year":"2010","journal-title":"Hypertension"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.25275","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/jcp.25275\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T02:08:06Z","timestamp":1653703686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.25275"}},"subtitle":["CARDIAC PROTECTION BY THYMOSIN \u03b24"],"short-title":[],"issued":{"date-parts":[[2016,3,16]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"URL":"https:\/\/doi.org\/10.1002\/jcp.25275","archive":["Portico"],"relation":{},"ISSN":["0021-9541"],"issn-type":[{"type":"print","value":"0021-9541"}],"subject":[],"published":{"date-parts":[[2016,3,16]]}}}