{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:25:48Z","timestamp":1771489548866,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Cell. Physiol."],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1002\/jcp.25286","type":"journal-article","created":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T09:33:13Z","timestamp":1449826393000},"page":"1635-1637","source":"Crossref","is-referenced-by-count":7,"title":["SGLT2 Inhibitors: Glucotoxicity and Tumorigenesis Downstream the Renal Proximal Tubule?"],"prefix":"10.1002","volume":"231","author":[{"given":"Romina","family":"Bertinat","sequence":"first","affiliation":[{"name":"Centro de Microscop\u00eda Avanzada, CMA-B\u00edo B\u00edo; Universidad de Concepci\u00f3n; Concepci\u00f3n Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Nualart","sequence":"additional","affiliation":[{"name":"Centro de Microscop\u00eda Avanzada, CMA-B\u00edo B\u00edo; Universidad de Concepci\u00f3n; Concepci\u00f3n Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro J.","family":"Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Centro de Microscop\u00eda Avanzada, CMA-B\u00edo B\u00edo; Universidad de Concepci\u00f3n; Concepci\u00f3n Chile"},{"name":"Instituto de Bioqu\u00edmica y Microbiolog\u00eda; Universidad Austral de Chile; Valdivia Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"key":"10.1002\/jcp.25286-BIB0001|jcp25286-cit-0001","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1161\/CIRCULATIONAHA.113.005081","article-title":"Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus","volume":"129","author":"Cherney","year":"2014","journal-title":"Circulation"},{"key":"10.1002\/jcp.25286-BIB0002|jcp25286-cit-0002","doi-asserted-by":"crossref","first-page":"F1053","DOI":"10.1152\/ajprenal.00006.2013","article-title":"Albuminuria induces a proinflammatory and profibrotic response in cortical collecting ducts via the 24p3 receptor","volume":"305","author":"Dizin","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1002\/jcp.25286-BIB0003|jcp25286-cit-0003","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1007\/s00125-007-0838-2","article-title":"Renal carcinogenesis in models of diabetes in rats: Metabolic changes are closely related to neoplastic development","volume":"50","author":"Dombrowski","year":"2007","journal-title":"Diabetologia"},{"key":"10.1002\/jcp.25286-BIB0004|jcp25286-cit-0004","doi-asserted-by":"crossref","first-page":"F1107","DOI":"10.1152\/ajprenal.00425.2013","article-title":"Proteinuria: It is time to look beyond the proximal tubule","volume":"305","author":"Erkan","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1002\/jcp.25286-BIB0005|jcp25286-cit-0005","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1177\/1479164114561992","article-title":"Probing SGLT2 as a therapeutic target for diabetes: Basic physiology and consequences","volume":"12","author":"Gallo","year":"2015","journal-title":"Diab Vasc Dis Res"},{"key":"10.1002\/jcp.25286-BIB0006|jcp25286-cit-0006","doi-asserted-by":"crossref","first-page":"e108994","DOI":"10.1371\/journal.pone.0108994","article-title":"Inhibition of kidney proximal tubular glucose reabsorption does not prevent against diabetic nephropathy in type 1 diabetic eNOS knockout mice","volume":"9","author":"Gangadharan Komala","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1002\/jcp.25286-BIB0007|jcp25286-cit-0007","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00418-014-1290-2","article-title":"Over-expression of muscle glycogen synthase in human diabetic nephropathy","volume":"143","author":"Gatica","year":"2015","journal-title":"Histochem Cell Biol"},{"key":"10.1002\/jcp.25286-BIB0008|jcp25286-cit-0008","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.3390\/jcm4101866","article-title":"Nephroprotection by hypoglycemic agents: Do we have supporting data","volume":"4","author":"Gorriz","year":"2015","journal-title":"J Clin Med"},{"key":"10.1002\/jcp.25286-BIB0009|jcp25286-cit-0009","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/MAJ.0000000000000185","article-title":"Diagnosis and treatment of diabetic kidney disease","volume":"347","author":"Gosmanov","year":"2014","journal-title":"Am J Med Sci"},{"key":"10.1002\/jcp.25286-BIB0010|jcp25286-cit-0010","doi-asserted-by":"crossref","first-page":"936518","DOI":"10.1155\/2012\/936518","article-title":"Functional expression of TRPV4 channels in human collecting duct cells: Implications for secondary hypertension in diabetic nephropathy","volume":"2012","author":"Hills","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"10.1002\/jcp.25286-BIB0011|jcp25286-cit-0011","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s00592-005-0188-9","article-title":"Glycogen accumulation in renal tubules, a key morphological change in the diabetic rat kidney","volume":"42","author":"Kang","year":"2005","journal-title":"Acta Diabetol"},{"key":"10.1002\/jcp.25286-BIB0012|jcp25286-cit-0012","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s12272-014-0419-0","article-title":"Clinical implication of SGLT2 inhibitors in type 2 diabetes","volume":"37","author":"Kim","year":"2014","journal-title":"Arch Pharm Res"},{"key":"10.1002\/jcp.25286-BIB0013|jcp25286-cit-0013","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00125-012-2805-9","article-title":"Attenuation of Armanni-Ebstein lesions in a rat model of diabetes by a new anti-fibrotic, anti-inflammatory agent, FT011","volume":"56","author":"Lau","year":"2013","journal-title":"Diabetologia"},{"key":"10.1002\/jcp.25286-BIB0014|jcp25286-cit-0014","doi-asserted-by":"crossref","first-page":"719578","DOI":"10.1155\/2014\/719578","article-title":"A review on the relationship between SGLT2 inhibitors and cancer","volume":"2014","author":"Lin","year":"2014","journal-title":"Int J Endocrinol"},{"key":"10.1002\/jcp.25286-BIB0015|jcp25286-cit-0015","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12933-014-0148-1","article-title":"Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice","volume":"13","author":"Lin","year":"2014","journal-title":"Cardiovasc Diabetol"},{"key":"10.1002\/jcp.25286-BIB0016|jcp25286-cit-0016","doi-asserted-by":"crossref","first-page":"F205","DOI":"10.1152\/ajprenal.00237.2004","article-title":"Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy","volume":"290","author":"Linden","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1002\/jcp.25286-BIB0017|jcp25286-cit-0017","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/ijc.29440","article-title":"Cancer risk in patients with type 2 diabetes mellitus and their relatives","volume":"137","author":"Liu","year":"2015","journal-title":"Int J Cancer"},{"key":"10.1002\/jcp.25286-BIB0018|jcp25286-cit-0018","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1681\/ASN.2010080888","article-title":"The sweet pee model for Sglt2 mutation","volume":"22","author":"Ly","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1002\/jcp.25286-BIB0019|jcp25286-cit-0019","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1055\/s-0034-1395609","article-title":"Empagliflozin, an inhibitor of sodium-glucose cotransporter 2 exerts anti-inflammatory and antifibrotic effects on experimental diabetic nephropathy partly by suppressing AGEs-receptor axis","volume":"47","author":"Ojima","year":"2015","journal-title":"Horm Metab Res"},{"key":"10.1002\/jcp.25286-BIB0020|jcp25286-cit-0020","doi-asserted-by":"crossref","first-page":"e54442","DOI":"10.1371\/journal.pone.0054442","article-title":"Effects of SGLT2 inhibition in human kidney proximal tubular cells-renoprotection in diabetic nephropathy","volume":"8","author":"Panchapakesan","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1002\/jcp.25286-BIB0021|jcp25286-cit-0021","doi-asserted-by":"crossref","first-page":"139","DOI":"10.7150\/jca.10429","article-title":"Could GLUT12 be a potential therapeutic target in cancer treatment? A preliminary report","volume":"6","author":"Pujol-Gimenez","year":"2015a","journal-title":"J Cancer"},{"key":"10.1002\/jcp.25286-BIB0022|jcp25286-cit-0022","doi-asserted-by":"crossref","first-page":"C1008","DOI":"10.1152\/ajpcell.00343.2014","article-title":"Functional characterization of the human facilitative glucose transporter 12 (GLUT12) by electrophysiological methods","volume":"308","author":"Pujol-Gimenez","year":"2015b","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1002\/jcp.25286-BIB0023|jcp25286-cit-0023","doi-asserted-by":"crossref","first-page":"13036","DOI":"10.18632\/oncotarget.3675","article-title":"PI3K\/AKT\/mTOR pathway plays a major pathogenetic role in glycogen accumulation and tumor development in renal distal tubules of rats and men","volume":"6","author":"Ribback","year":"2015","journal-title":"Oncotarget"},{"key":"10.1002\/jcp.25286-BIB0024|jcp25286-cit-0024","doi-asserted-by":"crossref","first-page":"F188","DOI":"10.1152\/ajprenal.00518.2013","article-title":"Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia","volume":"306","author":"Rieg","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1002\/jcp.25286-BIB0025|jcp25286-cit-0025","first-page":"1035","article-title":"The pathology of Armanni-Ebstein diabetic nephropathy","volume":"33","author":"Ritchie","year":"1957","journal-title":"Am J Pathol"},{"key":"10.1002\/jcp.25286-BIB0026|jcp25286-cit-0026","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cmet.2012.11.010","article-title":"Linking glycogen and senescence in cancer cells","volume":"16","author":"Ros","year":"2012","journal-title":"Cell Metab"},{"key":"10.1002\/jcp.25286-BIB0027|jcp25286-cit-0027","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2215\/CJN.04010609","article-title":"Familial renal glucosuria and SGL T2: From a mendelian trait to a therapeutic target","volume":"5","author":"Santer","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1002\/jcp.25286-BIB0028|jcp25286-cit-0028","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/ncpneph0757","article-title":"Mechanisms of disease: The hypoxic tubular hypothesis of diabetic nephropathy","volume":"4","author":"Singh","year":"2008","journal-title":"Nat Clin Pract Nephrol"},{"key":"10.1002\/jcp.25286-BIB0029|jcp25286-cit-0029","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1210\/jc.2009-0162","article-title":"Insulin-stimulated translocation of glucose transporter (GLUT) 12 parallels that of GLUT4 in normal muscle","volume":"94","author":"Stuart","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/jcp.25286-BIB0030|jcp25286-cit-0030","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00210-011-0713-z","article-title":"Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo","volume":"385","author":"Tahara","year":"2012","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1002\/jcp.25286-BIB0031|jcp25286-cit-0031","doi-asserted-by":"crossref","first-page":"F156","DOI":"10.1152\/ajprenal.00409.2012","article-title":"Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus","volume":"304","author":"Vallon","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1002\/jcp.25286-BIB0032|jcp25286-cit-0032","doi-asserted-by":"crossref","first-page":"F194","DOI":"10.1152\/ajprenal.00520.2013","article-title":"SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice","volume":"306","author":"Vallon","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1002\/jcp.25286-BIB0033|jcp25286-cit-0033","doi-asserted-by":"crossref","first-page":"R1009","DOI":"10.1152\/ajpregu.00809.2010","article-title":"The proximal tubule in the pathophysiology of the diabetic kidney","volume":"300","author":"Vallon","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1002\/jcp.25286-BIB0034|jcp25286-cit-0034","doi-asserted-by":"crossref","first-page":"C22","DOI":"10.1152\/ajpcell.00227.2007","article-title":"Proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells","volume":"294","author":"Vogetseder","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1002\/jcp.25286-BIB0035|jcp25286-cit-0035","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1442-2042.2007.01744.x","article-title":"Diabetes mellitus and kidney cancer risk: The results of Japan Collaborative Cohort Study for evaluation of cancer risk (JACC Study)","volume":"14","author":"Washio","year":"2007","journal-title":"Int J Urol"},{"key":"10.1002\/jcp.25286-BIB0036|jcp25286-cit-0036","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1210\/en.2007-0985","article-title":"Mitogen-stimulated and rapamycin-sensitive glucose transporter 12 targeting and functional glucose transport in renal epithelial cells","volume":"149","author":"Wilson-O'Brien","year":"2008","journal-title":"Endocrinology"},{"key":"10.1002\/jcp.25286-BIB0037|jcp25286-cit-0037","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/jcp.20183","article-title":"Different involvement for aldolase isoenzymes in kidney glucose metabolism: Aldolase B but not aldolase A colocalizes and forms a complex with FBPase","volume":"202","author":"Yanez","year":"2005","journal-title":"J Cell Physiol"},{"key":"10.1002\/jcp.25286-BIB0038|jcp25286-cit-0038","doi-asserted-by":"crossref","first-page":"317507","DOI":"10.1155\/2015\/317507","article-title":"Sodium-glucose linked transporter-2 inhibitors in chronic kidney disease","volume":"2015","author":"Zanoli","year":"2015","journal-title":"Sci World J"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.25286","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/jcp.25286\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T11:58:57Z","timestamp":1625313537000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.25286"}},"subtitle":["SGLT2 INHIBITORS: EFFECTS ON DISTAL NEPHRON"],"short-title":[],"issued":{"date-parts":[[2015,12,30]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"URL":"https:\/\/doi.org\/10.1002\/jcp.25286","archive":["Portico"],"relation":{},"ISSN":["0021-9541"],"issn-type":[{"value":"0021-9541","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12,30]]}}}