{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:19:26Z","timestamp":1791195566839,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T00:00:00Z","timestamp":1478736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"crossref","award":["NSC 97-2314-B-038-004-MY3"],"award-info":[{"award-number":["NSC 97-2314-B-038-004-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"crossref","award":["MOST102-2314-B-400-005-MY3"],"award-info":[{"award-number":["MOST102-2314-B-400-005-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>Valproic acid (VPA), with inhibition activity mainly toward histone deacetylase (HDAC) and Glycogen Synthase Kinase (GSK)\u20103, and lithium, with inhibition activity mainly toward GSK\u20103, are both prescribed in clinical as mood\u2010stabilizers and anticonvulsants for the control of bipolar disorder. This study aims to compare the immuno\u2010modulation activities of VPA and lithium, especially on the differentiation and functions of dendritic cells (DC). Our data show that treatment with VPA or lithium effectively alleviated the severity of collagen\u2010induced arthritis triggered by LPS in mice. Both agents reduced the serum level of IL\u20106 and IL\u201010 after LPS challenge in mice. VPA and lithium both induce significant down\u2010regulation of group I CD1 expression and secretion of IL\u20106 during differentiation of human monocyte\u2010derived immature DC, while they differ in the induction of CD83 and CD86 expression, secretion of IL\u20108, IL\u201010, and TNF\u2010\u03b1. Upon stimulation of immature DC with LPS, VPA, and lithium both reduced the secretion of IL\u20106 and TNF\u2010\u03b1. However, only lithium significantly increased the production of IL\u201010, while VPA increased the production of IL\u20108 but substantially reduce the secretion of IL\u201010 and IL\u201023. Treatment with VPA resulted in a reduced capacity of LPS\u2010stimulated DC to promote the differentiation of T helper 17 cells that are critical in the promotion of inflammatory responses. Taken together, our results suggest that VPA and lithium may differentially modulate inflammation through regulating the capacity of DC to mediate distinct T cell responses, and they may provide a complementary immunomodulatory effects for the treatment of inflammation\u2010related diseases. J. Cell. Physiol. 232: 1176\u20131186, 2017. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.25604","type":"journal-article","created":{"date-parts":[[2016,9,17]],"date-time":"2016-09-17T19:32:41Z","timestamp":1474140761000},"page":"1176-1186","source":"Crossref","is-referenced-by-count":51,"title":["Valproic Acid and Lithium Meditate Anti\u2010Inflammatory Effects by Differentially Modulating Dendritic Cell Differentiation and Function"],"prefix":"10.1002","volume":"232","author":[{"given":"Sy\u2010Jye","family":"Leu","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Center for Reproductive Medicine and Sciences Taipei Medical University Taipei 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