{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:34:58Z","timestamp":1790206498682,"version":"4.1.0"},"reference-count":77,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T00:00:00Z","timestamp":1475193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Science Center","award":["2015\/17\/B\/NZ4\/02658"],"award-info":[{"award-number":["2015\/17\/B\/NZ4\/02658"]}]},{"name":"National Science Center","award":["2014\/14\/E\/NZ4\/00358"],"award-info":[{"award-number":["2014\/14\/E\/NZ4\/00358"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>Podocytes and their foot processes form an important cellular layer of the glomerular barrier involved in the regulation of glomerular permeability. Disturbing the function of podocytes plays a central role in the development of proteinuria in diabetic nephropathy. Retraction of the podocyte foot processes that form slit diaphragms is a common feature of proteinuria; although, the correlation between these events in not well understood. Notably, it is unclear whether podocyte foot processes are able to regulate slit diaphragm permeability and glomerular ultrafiltration. The occurrence of reactive oxygen species generation, insulin resistance, and hyperglycemia characterizes early stages of type 2 diabetes. Protein kinase G type I alpha (PKGI\u03b1) is an intracellular target for vasorelaxant factors. It is activated in both cGMP\u2010dependent and cGMP\u2010independent manners. Recently, we demonstrated a relationship between oxidative stress, PKGI\u03b1 activation, actin reorganization, and changes in the permeability of the filtration barrier. This review discusses how redox imbalance affects both the activity of PKGI\u03b1 and PKGI\u2010dependent signaling pathways in podocytes. J. Cell. Physiol. 232: 691\u2013697, 2017. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.25613","type":"journal-article","created":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T22:43:51Z","timestamp":1474670631000},"page":"691-697","source":"Crossref","is-referenced-by-count":16,"title":["Role of Protein Kinase G and Reactive Oxygen Species in the Regulation of Podocyte Function in Health and Disease"],"prefix":"10.1002","volume":"232","author":[{"given":"Agnieszka","family":"Piwkowska","sequence":"first","affiliation":[{"name":"Mossakowski Medical Research Centre Polish Academy of Sciences Laboratory of Molecular and Cellular Nephrology Gda\u0144sk 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