{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:05:35Z","timestamp":1792782335056,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T00:00:00Z","timestamp":1487203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"IRCCS Burlo Garofolo","award":["RC 26\/13"],"award-info":[{"award-number":["RC 26\/13"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Biomarkers have a wide application in research and clinic, they help to choose the correct treatment for diseases. Recent studies, addressing the vaginal microbiome using next generation sequencing (NGS), reported the involvement of bacterial species in infertility. We compared the vaginal microbiome of idiopathic infertile women with that of healthy, including bacterial vaginosis affected women and non\u2010idiopathic infertile women, to identify bacterial species suitable as biomarkers. Information on microorganisms was obtained from the V3\u201016S rDNA sequencing of cervical\u2013vaginal fluids of 96 women using the Ion Torrent platform. Data were processed with QIIME and classified against the Vaginal 16S rDNA Reference Database. The analysis revealed a significant beta\u2010diversity variation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) between the four groups included in the study.\n                      <jats:italic>L<\/jats:italic>\n                      .\n                      <jats:italic>iners<\/jats:italic>\n                      ,\n                      <jats:italic>L<\/jats:italic>\n                      .\n                      <jats:italic>crispatus<\/jats:italic>\n                      , and\n                      <jats:italic>L<\/jats:italic>\n                      .\n                      <jats:italic>gasseri<\/jats:italic>\n                      distinguished idiopathic infertile women from the other groups. In these women, a microbial profile similar to that observed in bacterial vaginosis women has been detected. Our results suggest that the quantitative assessment and identification of specific microorganisms of the cervical\u2013vaginal microflora could increase the accuracy of available tools for the diagnosis of infertility and improve the adoption of therapeutic protocols.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.25806","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T07:13:31Z","timestamp":1484723611000},"page":"1681-1688","source":"Crossref","is-referenced-by-count":87,"title":["Subclinical alteration of the cervical\u2013vaginal microbiome in women with idiopathic infertility"],"prefix":"10.1002","volume":"232","author":[{"given":"Giuseppina","family":"Campisciano","sequence":"first","affiliation":[{"name":"Department of Medical Sciences University of Trieste Trieste 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