{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:59:01Z","timestamp":1787169541302,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T00:00:00Z","timestamp":1495065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Neural stem cells (NSCs) are multipotent self\u2010renewing cells that could be used in cellular\u2010based therapy for a wide variety of neurodegenerative diseases including Alzheimer's diseases (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Being multipotent in nature, they are practically capable of giving rise to major cell types of the nervous tissue including neurons, astrocytes, and oligodendrocytes. This is in marked contrast to neural progenitor cells which are committed to a specific lineage fate. In previous studies, we have demonstrated the ability of NSCs isolated from human olfactory bulb (OB) to survive, proliferate, differentiate, and restore cognitive and motor deficits associated with AD, and PD rat models, respectively. The use of carbon nanotubes (CNTs) to enhance the survivability and differentiation potential of NSCs following their in vivo engraftment have been recently suggested. Here, in order to assess the ability of CNTs to enhance the therapeutic potential of human OBNSCs for restoring cognitive deficits and neurodegenerative lesions, we co\u2010engrafted CNTs and human OBNSCs in TMT\u2010neurodegeneration rat model. The present study revealed that engrafted human OBNSCS\u2010CNTs restored cognitive deficits, and neurodegenerative changes associated with TMT\u2010induced rat neurodegeneration model. Moreover, the CNTs seemed to provide a support for engrafted OBNSCs, with increasing their tendency to differentiate into neurons rather than into glia cells. The present study indicate the marked ability of CNTs to enhance the therapeutic potential of human OBNSCs which qualify this novel therapeutic paradigm as a promising candidate for cell\u2010based therapy of different neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.25826","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T06:33:03Z","timestamp":1485325983000},"page":"3586-3597","source":"Crossref","is-referenced-by-count":36,"title":["Nanotubes impregnated human olfactory bulb neural stem cells promote neuronal differentiation in Trimethyltin\u2010induced neurodegeneration rat model"],"prefix":"10.1002","volume":"232","author":[{"given":"Hany E.","family":"Marei","sequence":"first","affiliation":[{"name":"Biomedical Research Center Qatar University Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed 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