{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:05:36Z","timestamp":1790431536659,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CIBERES"],"award-info":[{"award-number":["CIBERES"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS 11\/02029"],"award-info":[{"award-number":["FIS 11\/02029"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS 14\/00713"],"award-info":[{"award-number":["FIS 14\/00713"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["2013\u20104130"],"award-info":[{"award-number":["2013\u20104130"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2014 SGR 464"],"award-info":[{"award-number":["2014 SGR 464"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>Strategies to treat cachexia are still at its infancy. Enhanced muscle protein breakdown and ubiquitin\u2010proteasome system are common features of cachexia associated with chronic conditions including lung cancer (LC). Poly(ADP\u2010ribose) polymerases (PARP), which play a major role in chromatin structure regulation, also underlie maintenance of muscle metabolism and body composition. We hypothesized that protein catabolism, proteolytic markers, muscle fiber phenotype, and muscle anabolism may improve in respiratory and limb muscles of LC\u2010cachectic Parp\u20101\u2010deficient (Parp\u20101<jats:sup>\u2212\/\u2212<\/jats:sup>) and Parp\u20102<jats:sup>\u2212\/\u2212<\/jats:sup> mice. In diaphragm and gastrocnemius of LC (LP07 adenocarcinoma) bearing mice (wild type, Parp\u20101<jats:sup>\u2212\/\u2212<\/jats:sup>, and Parp\u20102<jats:sup>\u2212\/\u2212<\/jats:sup>), PARP activity (ADP\u2010ribose polymers, pADPr), redox balance, muscle fiber phenotype, apoptotic nuclei, tyrosine release, protein ubiquitination, muscle\u2010specific E3 ligases, NF\u2010\u03baB signaling pathway, markers of muscle anabolism (Akt, mTOR, p70S6K, and mitochondrial DNA) were evaluated along with body and muscle weights, and limb muscle force. Compared to wild type cachectic animals, in both respiratory and limb muscles of Parp\u20101<jats:sup>\u2212\/\u2212<\/jats:sup> and Parp\u20102<jats:sup>\u2212\/\u2212<\/jats:sup> cachectic mice: cancer induced\u2010muscle wasting characterized by increased PARP activity, protein oxidation, tyrosine release, and ubiquitin\u2010proteasome system (total protein ubiquitination, atrogin\u20101, and 20S proteasome C8 subunit) were blunted, the reduction in contractile myosin and atrophy of the fibers was attenuated, while no effects were seen in other structural features (inflammatory cells, internal or apoptotic nuclei), and markers of muscle anabolism partly improved. Activation of either PARP\u20101 or \u20102 is likely to play a role in muscle protein catabolism via oxidative stress, NF\u2010\u03baB signaling, and enhanced proteasomal degradation in cancer\u2010induced cachexia. Therapeutic potential of PARP activity inhibition deserves attention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.25851","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T11:32:56Z","timestamp":1486553576000},"page":"3744-3761","source":"Crossref","is-referenced-by-count":46,"title":["Role of PARP activity in lung cancer\u2010induced cachexia: Effects on muscle oxidative stress, proteolysis, anabolic markers, and phenotype"],"prefix":"10.1002","volume":"232","author":[{"given":"Alba","family":"Chacon\u2010Cabrera","sequence":"first","affiliation":[{"name":"Pulmonology Department\u2010Lung Cancer and Muscle Research Group, IMIM\u2010Hospital del Mar, Health and Experimental Sciences Department (CEXS) Universitat Pompeu Fabra (UPF) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Respiratorias (CIBERES) Instituto de Salud Carlos III (ISCIII) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Mateu\u2010Jimenez","sequence":"additional","affiliation":[{"name":"Pulmonology Department\u2010Lung Cancer and Muscle Research Group, IMIM\u2010Hospital del Mar, Health and Experimental Sciences Department (CEXS) Universitat Pompeu Fabra (UPF) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Respiratorias (CIBERES) Instituto de Salud Carlos III (ISCIII) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Langohr","sequence":"additional","affiliation":[{"name":"Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program Hospital del Mal Medical Research Institute (IMIM) Barcelona Spain"},{"name":"Department of Statistics and Operations Research Universitat Polit\u00e8cnica de Barcelona\/Barcelonatech Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Fermoselle","sequence":"additional","affiliation":[{"name":"Pulmonology Department\u2010Lung Cancer and Muscle Research Group, IMIM\u2010Hospital del Mar, Health and Experimental Sciences Department (CEXS) Universitat Pompeu Fabra (UPF) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Garc\u00eda\u2010Arum\u00ed","sequence":"additional","affiliation":[{"name":"Unitat de Patologia Neuromuscular i Mitocondrial, Hospital Universitari Vall d'Hebron Institut de Recerca (VHIR) Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), ISCIII Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni L.","family":"Andreu","sequence":"additional","affiliation":[{"name":"Unitat de Patologia Neuromuscular i Mitocondrial, Hospital Universitari Vall d'Hebron Institut de Recerca (VHIR) Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), ISCIII Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Yelamos","sequence":"additional","affiliation":[{"name":"Cancer Research Program\u2010Immunology Hospital del Mar Medical Research Institute (IMIM)\u2010Hospital del Mar Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Instituto de Salud Carlos III (ISCIII) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Barreiro","sequence":"additional","affiliation":[{"name":"Pulmonology Department\u2010Lung Cancer and Muscle Research Group, IMIM\u2010Hospital del Mar, Health and Experimental Sciences Department (CEXS) Universitat Pompeu Fabra (UPF) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Respiratorias (CIBERES) Instituto de Salud Carlos III (ISCIII) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,27]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"2","article-title":"Recommendations of the Spanish Society of Pneumology and Thoracic Surgery on the diagnosis and treatment of non\u2010small\u2010cell lung cancer","volume":"52","author":"Alvarez F. V.","year":"2016","journal-title":"Archivos de Bronconeumologia"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2009.02.006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.03.013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.03.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.11.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2016.08.006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0396.2010.01027.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200908-1220OC"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25241"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.078030"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.12.010"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/59.5.B416"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2015.09.020"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24611"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25635"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164951"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62329-2"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.14.7303"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00928438"},{"key":"e_1_2_10_21_1","first-page":"45","article-title":"Spontaneous murine lung adenocarcinoma (P07): A new experimental model to study paraneoplastic syndromes of lung cancer","volume":"2","author":"Diament M. J.","year":"1998","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2014.01.007"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047978"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.06.013"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2013.072496"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00137211"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2011.11.002"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23893"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.11.009"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/2044-5040-1-11"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.24.13978"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.1999.118"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.200810425"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200205000-00019"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2301-x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-270-0_8"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2014.03.019"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2818"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00072008"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2015.11.030"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10490"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1364"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.07.026"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134227"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.16.4446"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2015.05.015"},{"key":"e_1_2_10_48_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.freeradbiomed.2014.11.006","article-title":"Oxidative stress, redox signaling pathways, and autophagy in cachectic muscles of male patients with advanced COPD and lung cancer","volume":"79","author":"Puig\u2010Vilanova E.","year":"2014","journal-title":"Free Radical Biology and Medicine"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00121-09"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-1003-9"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2015.06.015"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2015.02.015"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2015.10.022"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01474.2012"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.1998"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(00)00399-3"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6223"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000299434.86640.15"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-010-0002-6"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/2044-5040-2-14"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024650"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02953-4"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002865"},{"key":"e_1_2_10_64_1","first-page":"328","article-title":"PARP\u20101 and PARP\u20102: New players in tumour development","volume":"1","author":"Yelamos J.","year":"2011","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00436.2003"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.011"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.25851","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.25851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T14:25:05Z","timestamp":1696343105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.25851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,27]]},"references-count":65,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/jcp.25851"],"URL":"https:\/\/doi.org\/10.1002\/jcp.25851","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,27]]}}}