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Due to the severe side\u2010effects caused by the currently available drugs, a continuous search for novel bone\u2010protective therapies is essential. Artesunate (Art), the water\u2010soluble derivative of artemisinin has been investigated owing to its anti\u2010malarial properties. However, its effects in osteoclastogenesis have not yet been reported. In this study, Art was shown to inhibit the nuclear factor\u2010\u03baB ligand (RANKL)\u2010induced osteoclastogenesis, the mRNA expression of osteoclastic\u2010specific genes, and resorption pit formation in a dose\u2010dependent manner in primary bone marrow\u2010derived macrophages cells (BMMs). Furthermore, Art markedly blocked the RANKL\u2010induced osteoclastogenesis by attenuating the degradation of I\u03baB and phosphorylation of NF\u2010\u03baB p65. Consistent with the in vitro results, Art inhibited lipopolysaccharide (LPS)\u2010induced bone resorption by suppressing the osteoclastogenesis. Together our data demonstrated that Art inhibits RANKL\u2010induced osteoclastogenesis by suppressing the NF\u2010\u03baB signaling pathway and that it is a promising agent for the treatment of osteolytic diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.25907","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T11:52:48Z","timestamp":1489578768000},"page":"476-485","source":"Crossref","is-referenced-by-count":48,"title":["Artesunate inhibits RANKL\u2010induced osteoclastogenesis and bone resorption in vitro and prevents LPS\u2010induced bone loss in vivo"],"prefix":"10.1002","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4361-6863","authenticated-orcid":false,"given":"Cheng\u2010Ming","family":"Wei","sequence":"first","affiliation":[{"name":"Research Centre for Regenerative Medicine and Guangxi Key Laboratory of Regenerative Medicine Guangxi Medical University Guangxi China"},{"name":"Orthopaedic Department The First Affiliated 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