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In addition, interleukin\u201010 (IL10) could attenuate MI through suppressing inflammation. Thus, the combination of MSC implantation with IL10 delivery may extend health benefits to ameliorate cardiac injury after MI. Here we established overexpression of IL10 in bone marrow\u2010derived MSC through adenoviral transduction. Cell viability, apoptosis, and IL10 secretion under ischemic challenge in vitro were examined. In addition, MSC was transplanted into the injured hearts in a rat model of MI. Four weeks after the MI induction, MI, cardiac functions, apoptotic cells, and inflammation cytokines were assessed. In response to in vitro oxygen\u2010glucose deprivation (OGD), IL10 overexpression in MSC (Ad.IL10\u2010MSC) enhanced cell viability, decreased apoptosis, and increased IL10 secretion. Consistently, the implantation of Ad.IL10\u2010MSCs into MI animals resulted in more reductions in myocardial infarct size, cardiac impairment, and cell apoptosis, compared to the individual treatments of either MSC or IL10 administration. Moreover, the attenuation of both systemic and local inflammations was most prominent for Ad.IL10\u2010MSC treatment. IL10 overexpression and MSC may exert a synergistic anti\u2010inflammatory effect to alleviate cardiac injury after MI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.25919","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T01:39:46Z","timestamp":1490146786000},"page":"587-595","source":"Crossref","is-referenced-by-count":39,"title":["Transplantation of mesenchymal stem cells overexpressing IL10 attenuates cardiac impairments in rats with myocardial infarction"],"prefix":"10.1002","volume":"233","author":[{"given":"Xin","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Ultrasonography Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi 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