{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:38:36Z","timestamp":1790807916088,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003852","name":"Regione Campania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003852","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002385","name":"Ministry of Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>In order to verify the effects of exposure to Cd and Zn on testicular DAAM1 gene and protein expression and also to ascertain their involvement in the protective role of Zn in prevent the testicular toxicity Cd\u2010induced in male offspring rats at adult age after gestational and lactational exposure, male offspring rats, from mothers receiving either tap water, Cd, Zn, or Cd\u2009+\u2009Zn during gestation and lactation periods, were scarified on postnatal days (PND) 70. The reproductive organ (testis, epididymis, and vesicle seminal) were collected, weighed, and analyzed. The results showed that exposure to Cd in utero and through lactation decreased the relative reproductive organ weight, altered the testicular histology at the interstitial and tubular levels, and causing a significant reduction in the daily sperm production (DSP) per testis and per gram of testis, and other then altering the epididymal sperm quality. Furthermore, both mRNA and protein expression of rat testicular DAAM1 were also inhibited in Cd\u2010treated group. Zn supply has completely corrected the most of these toxic effects. Our results imply that Zn could prevent Cd\u2010induced testicular toxicity and sperm quality alteration in adult male rat after gestational and lactational exposure, probably via the restoration of the testicular DAAM1 expression inhibited by Cd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.25923","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T04:58:34Z","timestamp":1490331514000},"page":"630-640","source":"Crossref","is-referenced-by-count":57,"title":["Involvement of testicular DAAM1 expression in zinc protection against cadmium\u2010induced male rat reproductive toxicity"],"prefix":"10.1002","volume":"233","author":[{"given":"Marouane","family":"Chemek","sequence":"first","affiliation":[{"name":"LR11ES41: G\u00e9n\u00e9tique, Biodiversit\u00e9 et Valorisation des Bioressources, Institut de Biotechnologie Universit\u00e9 de Monastir Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Venditti","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Sperimentale, Sez. 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